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Autologous Point-of-Care Adipose Therapy for Burns and Surgical Injuries

This study is looking at a new way to treat severe burns, contracture scars, and surgical injuries using your own body fat. It's called "Autologous Layered Composite Grafting" and involves taking a small amount of your fat through liposuction and placing it directly into the wound, along with a skin graft (Split Thickness Skin Graft or STSG). Researchers want to see if this method helps wounds heal better, reduces scarring, and lowers the risk of infection compared to traditional treatments. They will measure how scars look and feel using a special scale after 9 months. You could be eligible if you are an adult (18 or older) with certain types of severe skin loss or injuries, including those from burns or trauma. The study is currently unclear on its recruitment status and plans to enroll 68 participants.

Study design
This interventional study compares a new fat grafting method to traditional treatments. Evaluators will be unaware of which treatment participants received (blinded).
What's involved
You will receive immediate fat grafting into your wound and a simultaneous skin graft for reconstruction. Scar assessment will be done at a 9-month follow-up visit.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 9 months after surgery to assess scar outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06857448

Autologous Point-of-Care Adipose Therapy: Recent Injury

Recruiting
NAAges 18+InterventionalTreatment
University of Pittsburgh
~68 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Split Thickness Skin Graft (STSG)Base of wound fat graft with STSG Reconstruction (Autologous Layered Composite Grafting).

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total score on the Patient and Observer Scar Assessment Scale (POSAS): Pigmentation, Pliability, Vascularity, Thickness, Relief, and Surface Area, collected at the 9 month follow up visit.
Measured over From surgery to 9-month clinical endpoint.

Conditions

Burns
Contracture Scar
Surgical Injury

Explore related trials

BurnContracture scarIncision of fasciaInjuries, SurgicalInjury

Where it's being run

2 sites across 1 states
Pennsylvania2

Study leadership

  • Francesco Egro · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Eleanor Shirley
[email protected]
412-641-8676
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

The proposed study will include adult patients 18 years of age or older,
male or female,
civilian, military, active duty or retired veterans
presenting for unilateral or bilateral fasciotomy of the extremity at any level necessary
secondary to non-infectious etiology,
unilateral or bilateral traumatic full-thickness skin loss of the face, head, neck or extremities necessitating reconstruction, and/or
full or partial thickness burn injury of the face, neck, or extremity requiring excision and/or reconstruction.

Exclusion

Age \< 18 years of age,
active infection,
medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,
unwilling or unable to comply with study procedures,
radiation to the site of interest,
prisoners and/or vulnerable populations.
In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.

What this trial measures

  • Total score on the Patient and Observer Scar Assessment Scale (POSAS): Pigmentation, Pliability, Vascularity, Thickness, Relief, and Surface Area, collected at the 9 month follow up visit.From surgery to 9-month clinical endpoint.

    POSAS measures subjective assessment on a 1-10 scale from normal skin to worst scar imaginable across 6 metrics (surface area, vascularity, pigmentation, thickness, pliability and relief). The lowest sum score, reflecting normal skin, is 6 and the highest score, reflecting the worst imaginable scar, is 60.