This study is looking at new ways to treat necrotizing soft tissue infections (a severe infection that causes tissue death, like necrotizing fasciitis). If you have this condition, your wound often needs many surgeries and a long time to heal before a skin graft can be done. This study is testing two medical devices, Cytal® Wound Matrix and MicroMatrix®, to see if they can help wounds heal faster and be ready for skin grafting sooner. Researchers will compare these devices to standard wound dressings. You might be able to join if you are an adult (18 or older) with a necrotizing fasciitis diagnosis and a wound at least 30 cm2 in size. The main goal is to see how quickly your wound becomes ready for grafting, up to 12 weeks after starting the study.

Study design

This is a pilot study that will randomly assign 50 participants to receive either the study devices or standard care. It is a single-center study conducted at the Cleveland Clinic Foundation.

What's involved

You would need to be willing to follow the study's requirements and attend follow-up appointments. Wound debridement procedures will be performed by surgical staff.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, time to readiness for grafting, will be measured up to 12 weeks after randomization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.