This study, called WISE-2B, aims to understand how weight loss and improvements in diabetes after bariatric (weight loss) surgery affect your brain function and thinking. Researchers are also looking at whether a non-invasive treatment called transcutaneous vagal nerve stimulation (tVNS), which uses small electrical currents to stimulate a nerve, can improve brain function after surgery. You could join if you are between 20 and 75 years old, speak English, are physically mobile, have a BMI over 35 before surgery, and are already planning to have bariatric surgery. The study will measure brain inflammation and your thinking abilities 18 months after surgery to see if these improve. The study status is currently unclear.

Study design

This is an interventional study with one group of participants, aiming to enroll 120 people. It is not specified if the study is randomized or blinded.

What's involved

You will have tests for thinking and memory at the start, after 12 weeks, and again at 18 months. You will also use a tVNS device at home for 30 days after surgery and have MRI brain scans and blood tests at each time point.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 18 months after surgery, with primary endpoints measured at this time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.