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Observational Study on Phosphatidylethanol and Surgical Outcomes

This study at University Hospitals is looking at how a substance called phosphatidylethanol (PEth) might be linked to how patients recover after surgery. PEth levels show how much alcohol someone has consumed in recent weeks. Researchers will measure PEth levels using a single blood draw, taken during your standard blood tests. They want to see if these levels are connected to problems that can happen after surgery, like longer stays in the Intensive Care Unit (ICU) or the hospital. You might be able to join if you are between 21 and 79 years old, having elective surgery at UHCMC, and are expected to stay in the hospital for at least three days, or are planned for ICU admission. The study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to include 170 participants.
What's involved
You would have a single blood sample taken for PEth testing, which will happen during your standard blood draw.
Compensation
Not stated in the trial record.
Follow-up
Your length of ICU stay will be measured for up to 7 days, and your length of hospital stay for up to 2 weeks.

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NCT06864819

Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

Recruiting
Not specifiedAges 21–79Observational
University Hospitals Cleveland Medical Center
~170 participants
Updated 2026-01-12 on ClinicalTrials.gov
What's tested:Blood Draw

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Phosphatidylethanol level as measured by blood draw.
Measured over Baseline
+3 more outcomes measured

Conditions

Postoperative Complications
Alcohol Use Disorder

Explore related trials

Alcohol use disorder

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Salim Hayek, MD, PhD · PRINCIPAL_INVESTIGATOR · University Hospitals

Who to contact

Ayse Ulucay, MD
[email protected]
216-844-3771
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

1\. Age range: 21-79
2\. Patients undergoing elective surgery at UHCMC with planned ICU admission
3\. Patients undergoing elective surgery at UHCMC with expected in-hospital admission for three or more days
4\. Only patients who consume alcoholic beverages on a regular basis.

Exclusion

1\. Patients undergoing same day outpatient surgeries or expected to be admitted less than three days post-operatively
2\. Subjects who have received a blood transfusion within the past month before surgery
3\. Pregnant subjects

What this trial measures

  • Phosphatidylethanol level as measured by blood draw.Baseline
  • Length of ICU stay measured in daysUp to 7 days
  • Length of hospital stay measured in daysUp to 2 weeks
  • Number of perioperative complications as measured by medical record review.Up to six months

    Perioperative complications including but not limited to delirium, pulmonary complications, cardiovascular complications, need for transfusion including amount transfused, post-operative infections, unexpected admission to the intensive care unit (ICU) and increased length of stay