Knee Injection Pain Study: Needle Size and Ethyl Chloride

This study is looking at ways to make knee injections for osteoarthritis (OA) less painful. Researchers want to see if using a smaller needle (25 gauge) or a numbing spray called ethyl chloride (or both) can reduce the pain you feel during and right after the injection. They will compare these to a slightly larger needle (22 gauge) and a placebo spray (isopropyl alcohol). The study will also look at how factors like fear of needles might affect your pain experience and if less pain during the injection leads to better long-term results for your knee. To join, you need to be between 40 and 89 years old, have knee osteoarthritis, and be scheduled for a steroid injection in your knee. The study is currently unclear on its recruitment status.

Study design
This interventional study plans to enroll 88 participants. It will compare different needle sizes and the use of ethyl chloride spray during knee injections.
What's involved
You would receive an intra-articular knee joint injection with steroids. Your pain will be measured immediately after the procedure and 24-48 hours later.
Compensation
Not stated in the trial record.
Follow-up
The study will assess improvements in knee osteoarthritis pain and functional scores at 6 weeks after the injection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06865170

Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?

Not Yet Recruiting
PHASE4Ages 40–89InterventionalHealth services
University of California, Davis
~88 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:25 gauge needle22 gauge needle+/- Ethyl Chloride Topical Aerosol Anesthetic

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
NRPS for injection-related pain at the time of the procedure
Measured over immediately following the procedure
Osteoarthritis (OA) of the Knee
Fear of Needles
1 sites across 1 states
California1

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  • NRPS for injection-related pain at the time of the procedureimmediately following the procedure

    NRPS = "Numeric Rating of Pain Scale", scale from 0 to 100. "0" = minimum score, better outcome); "100" (maximum score, worse outcome)