Aspirin to Prevent Blood Clots in Advanced Germ Cell Tumors
This study is looking at whether taking a low dose of aspirin (81 mg daily) can help prevent blood clots (venous thromboembolism or VTE) in people with advanced germ cell tumors, including testicular cancer. You would take aspirin for 26 weeks while also receiving your standard chemotherapy. The study wants to see how many participants remain free of blood clots during this time. To join, you need to be between 18 and 70 years old and have a confirmed diagnosis of advanced germ cell cancer. The study is currently enrolling participants.
- Study design
- This is a single-arm, two-stage Phase II study, meaning all participants receive the same treatment. It plans to enroll up to 31 participants.
- What's involved
- You would take 81 mg of aspirin by mouth daily for 26 weeks. You will need to provide your own supply of aspirin.
- Compensation
- Not stated in the trial record.
- Follow-up
- The main goal is measured at 26 weeks after starting chemotherapy, which is when you would also be taking aspirin.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy
At a glance
Conditions
Where it's being run
3 sites across 2 statesStudy leadership
- Landon Brown, MD · PRINCIPAL_INVESTIGATOR · Atrium Health Wake Forest Baptist Comprehensive Cancer Center
Who to contact
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What this trial measures
- Venous thromboembolism (VTE)-free26 weeks after initiation of standard chemotherapy
A binary variable indicating whether the participant had zero VTE events within 26 weeks of initiation of standard chemotherapy. VTE events include objectively confirmed symptomatic or asymptomatic proximal deep-vein thrombosis in a lower limb, symptomatic deep-vein thrombosis in an upper limb or distal deep-vein thrombosis in a lower limb, symptomatic or incidental pulmonary embolism, symptomatic or incidental central catheter related thrombosis, or death from venous thromboembolism.