Ketone Ester and Salt (KEAS) in Older Adults
This study is looking at how a ketone supplement, called β-hydroxybutyrate (β-OHB), might help older adults counteract the effects of a high-salt diet. Many Americans eat too much salt, which can raise blood pressure and increase the risk of heart and kidney problems, especially in older adults. Researchers want to see if β-OHB can help manage blood pressure even when salt intake is high. You may be able to join if you are between 60 and 85 years old, have resting blood pressure no higher than 150/90, and are generally healthy without certain medical conditions like diabetes or heart disease. The study aims to enroll 35 participants and will measure changes in your resting blood pressure and how your blood pressure reacts to different situations.
- Study design
- This interventional study plans to enroll 35 participants. It will compare the effects of different dietary interventions on blood pressure.
- What's involved
- Participants will consume different dietary supplements (with or without salt and β-OHB) for ten days each, over a period of 3-4 months. Blood pressure will be measured on day 10 of each 10-day intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- Blood pressure measurements are completed on day 10 of each 10-day intervention over 3-4 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Ketone Ester And Salt (KEAS) in Older Adults
At a glance
Conditions
NCT06868719
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
School of Public Health
Bloomington, Indianastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Resting blood pressureThis measure is completed on day 10 of each 10-day intervention (low salt, high salt, high salt+ ketone) over 3-4 months and values will be compared across interventions.
The investigators will measure systolic and diastolic pressure using a validated oscillometric device (Suntech CT40)
- Blood pressure reactivity responsesThis measure is completed on day 10 of each 10-day intervention (low salt, high salt, high salt + ketone) over 3-4 months and values will be compared across interventions.
The investigators will measure systolic and diastolic pressure using photoplethysmography at the finger and manually measure brachial pressures. Systolic and diastolic blood pressure will be assessed at rest and during submaximal cycling exercise. Blood pressure reactivity will be expressed as a change in pressure (mmHg) from baseline to a predetermined time during the stressor.