Building Research for Intervention Development in Gliosis and Eating Habits

This study is looking at how nutritious foods affect inflammation in the brain (hypothalamus) of children, and if providing these foods is practical and acceptable for children who are overweight or have obesity. Specifically, in one part of the study, children will receive all their meals for 7 days, consisting of nutritious foods with more calories than they need, and they'll be asked to eat as much as they want. The main goal is to measure changes in brain inflammation using an MRI scan after 7 days of this diet. You might be able to join if you are a child aged 9-11 years, and depending on the study part, your BMI (Body Mass Index) may need to be between the 85th and 95th percentile, or your family might qualify for free or reduced-cost lunch in Washington State. The study is currently unclear on its recruitment status and plans to enroll 75 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 75 participants.
What's involved
In one part of the study, children will be provided all meals for a 7-day period. An MRI scan of the brain will be performed at 7 days.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06870578

Building Research for Intervention Development in Gliosis and Eating Habits

Recruiting
NAAges 9+InterventionalBasic science
University of Washington
~75 participants
Updated 2025-06-06 on ClinicalTrials.gov
What's tested:Diet modification

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
T2 relaxation time by brain MRI
Measured over 7 days of diet intervention
Gliosis
Child Obesity
Eating
1 sites across 1 states
Washington1
  • Ellen Schur, MD · PRINCIPAL_INVESTIGATOR · University of Washington

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Eligibility criteria

Inclusion

Study1: Adult caregiver and Child age 9-11y. Willing to come to in-person focus group
Study 2: Age 9-11y, BMI ≥85th and ≤95th percentile for age and sex
Study 3:Adult caregiver with child who qualify for free or reduced-cost lunch in WA State. Child age 9-11y and with overweight.

Exclusion

Significant health conditions including type 2 diabetes
History of major weight loss or eating disorder
Current use of medications known to alter appetite or body weight (e.g., stimulants for ADHD)
Documented cognitive disorder
Severe food allergies, vegetarian, or vegan (Study 1 only)
Unable to make the session date
Significant health conditions including type 2 diabetes
History of major weight loss or eating disorder
Current use of medications known to alter appetite or body weight (e.g., stimulants for ADHD)
Documented cognitive disorder
MRI contraindication (e.g., braces, claustrophobia)
Weight \>330 pounds (MRI limit)
Severe food allergies, vegetarian, or vegan
Currently in formal weight loss program
  • T2 relaxation time by brain MRI7 days of diet intervention