This study is looking at firefighters aged 40-49 to see if their job exposure increases the risk of developing pre-cancerous blood conditions like Clonal Hematopoiesis of Indeterminate Potential (CHIP) or Monoclonal Gammopathy, which can sometimes lead to blood cancers such as Non-Hodgkin Lymphoma, Leukemia, or Multiple Myeloma. You would have blood collected to check for these conditions using tests like Complete Blood Count with differential (CBC w/ diff), Monoclonal Gammopathy (SPEP, immunofixation, and free light chains), and Clonal hematopoiesis (CHIP) (next generation sequencing). The study aims to understand if these pre-cancerous states are more common in firefighters. If abnormal results are found, you would be referred for further medical evaluation. This is an observational study, meaning no specific treatment is being tested, and it is currently unclear if they are actively enrolling participants.

Study design

This is an observational study planning to enroll 300 participants. It is not specified if it is randomized or blinded.

What's involved

You would have blood collected at a baseline visit for various tests and complete a Firefighter History Assessment. Buccal swabs and remaining blood may also be collected for future research if you consent.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, Clonal Hematopoiesis (CHIP), is measured from enrollment to availability of lab results, approximately 6 months. If abnormal results are found, you would be referred for further diagnostic work-up, and the final diagnosis would be collected.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.