Clinical Decision Support for Opioid Use Disorder in the Emergency Department

This study is looking at ways to improve care for people with opioid use disorder (OUD) in the emergency department (ED). Researchers are testing two versions of a computer tool called Clinical Decision Support (CDS). One version, CDSv1, helps ED doctors prescribe buprenorphine, a medication for OUD. The other version, CDSv2, adds information about a patient's social needs (like housing or food) to CDSv1. The goal is to see if CDSv2 helps more patients stick with their OUD treatment and follow-up care. The study aims to enroll 300 people. Success will be measured by how often doctors use these tools over 12 months. You may be able to join if you are an English-speaking patient aged 18 or older with OUD who receives medication treatment in the UCSF ED.

Study design
This is an interventional study comparing two versions of a clinical decision support tool. It will involve approximately 300 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study measures how often the tools are used over 12 months.

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NCT06872190

Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

Recruiting
NAAges 18+InterventionalHealth services
University of California, San Francisco
~300 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:ED-Based Clinical Decision Support for Opioid Use DisorderSocial Care-Enhanced Clinical Decision Support for Opioid Use Disorder

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
CDSv1 clinician launch
Measured over 12 months
+18 more outcomes measured
Opioid Use Disorder
Social Determinants of Health (SDOH)
1 sites across 1 states
California1
  • Melanie F Molina, MD, MAS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

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Eligibility criteria

Inclusion

All University of California, San Francisco ED providers (residents, attendings, advanced practice providers) who have used either CDSv1 or CDSv2 will be eligible to participate in surveys and interviews regarding feasibility and acceptability.
English-speaking patients ≥18 years of age presenting to the UCSF ED with opioid use disorder who receive medication treatment (as a result of CDSv1 or CDSv2) will be eligible to participate.

Exclusion

they have a medical or psychiatric condition requiring hospitalization at the index ED visit,
are actively suicidal, are cognitively impaired,
present from an extended care facility, or
require opioids for a pain condition.
  • CDSv1 clinician launch12 months

    Percentage of ED clinicians who launch CDSv1 for patients with OUD

  • CDSv1 encounter launch12 months

    Percentage of eligible encounters (i.e., encounters including patients with OUD as defined by the EHR-derived phenotype) where CDSv1 was launched by clinician

  • CDSv2 clinician launch12 months

    Percentage of ED clinicians who launch CDSv2 for patients with OUD

  • CDSv2 encounter launch12 months

    Percentage of eligible encounters (i.e., encounters including patients with OUD as defined by the EHR-derived phenotype) where CDSv2 was launched by clinician

  • CDSv1 adherence to OUD treatment recommendations12 months

    For ED visits in which CDSv1 is launched, investigators will assess the percentage of times either buprenorphine, methadone, or naltrexone was prescribed by an ED clinician

  • CDSv2 adherence to OUD treatment recommendations12 months

    For ED visits in which CDSv2 is launched, investigators will assess the percentage of times either buprenorphine, methadone, or naltrexone was prescribed by an ED clinician

  • CDSv2 adherence to social care recommendations12 months

    For ED visits in which CDSv2 is launched, investigators will assess the percentage of times social care recommendations (to be determined, based on results from Aim 2) were followed by ED clinicians

  • CDSv1 acceptabilityDuring first 6 months of CDSv1 deployment

    Acceptability of Intervention Measure 4-item survey to assess clinician acceptability of CDSv1. Response scales range from "1 = Completely disagree" to "5 = Completely agree", with higher scores indicating greater success.

  • CDSv1 appropriatenessDuring first 6 months of CDSv1 deployment

    Intervention Appropriateness Measure 4-item survey to assess clinician perception of CDSv1 appropriateness. Response scales range from "1 = Completely disagree" to "5 = Completely agree", with higher scores indicating greater success.

  • CDSv2 acceptabilityDuring first 6 months of CDSv2 deployment

    Acceptability of Intervention Measure 4-item survey to assess clinician acceptability of CDSv2. Response scales range from "1 = Completely disagree" to "5 = Completely agree", with higher scores indicating greater success.

  • CDSv2 appropriatenessDuring first 6 months of CDSv2 deployment

    Intervention Appropriateness Measure 4-item survey to assess clinician perception of CDSv2 appropriateness. Response scales range from "1 = Completely disagree" to "5 = Completely agree", with higher scores indicating greater success.

  • Patient recruitment CDSv112 months

    Number of patients who receive OUD medication as a result of CDSv1 who are enrolled for primary outcome ascertainment

  • Patient recruitment CDSv212 months

    Number of patients who receive OUD medication as a result of CDSv2 who are enrolled for primary outcome ascertainment

  • ED clinicians' perceptions of CDSv1Within first 8 months of CDSv1 deployment

    Themes emerging from semi-structured qualitative interviews exploring clinician perceptions of CDSv1

  • ED patients' perceptions of CDSv1Within first 8 months of CDSv1 deployment

    Themes emerging from semi-structured qualitative interviews exploring patient perceptions of receiving treatment from CDSv1

  • ED clinicians' perceptions of CDSv2Within first 8 months of CDSv2 deployment

    Themes emerging from semi-structured qualitative interviews exploring clinician perceptions of CDSv2

  • ED patients' perceptions of CDSv2Within first 8 months of CDSv2 deployment

    Themes emerging from semi-structured qualitative interviews exploring patient perceptions of receiving social risk-informed treatment from CDSv2

  • Feasibility of primary endpoint collection for CDSv113 months

    Percentage of participants for whom data on OUD medication adherence and follow up are successfully collected at 30 days for CDSv1

  • Feasibility of primary endpoint collection for CDSv213 months

    Percentage of participants for whom data on OUD medication adherence and follow up are successfully collected at 30 days for CDSv2