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Study of 11C-JMJ-129 for Brain and Body Imaging

This study is looking for healthy volunteers aged 18 to 101 to help researchers learn more about a protein called PDE4D, which is involved in thinking and depression. We are testing a new substance called 11C-JMJ-129, which is given through an IV and then followed by PET scans. This substance is designed to attach to PDE4D so we can see it in the brain and body. Early studies showed that 11C-JMJ-129 might break down too quickly, making it hard to get clear images. This study will help us understand how 11C-JMJ-129 works in the body and if a medication called disulfiram can improve the imaging results. We plan to enroll 40 healthy participants to measure how much of the substance is distributed in the brain after 120 minutes.

Study design
This is an interventional study involving 40 healthy volunteers. It focuses on understanding how 11C-JMJ-129 works in the body.
What's involved
You would receive an IV injection of 11C-JMJ-129 followed by PET scanning. The primary measurement will be taken at 120 minutes.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 120 minutes after the injection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06874205

Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

Recruiting
PHASE1Ages 18+InterventionalDiagnostic
National Institute of Mental Health (NIMH)
~40 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:11C-JMJ-129

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Volume of Distribution
Measured over 120 minutes

Conditions

Healthy

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Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • National Institutes of Health Clinical Center

    Bethesda, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Robert B Innis, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Mental Health (NIMH)

Who to contact

Tara N Turon, C.R.N.P.
[email protected]
(301) 827-6599
Email the study team

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Eligibility criteria

Inclusion

Aged 18 years or older.
Participants must have undergone a screening assessment under protocol 01-M-0254, "The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Participants."
Healthy based on medical history, physical examination, and laboratory testing.
Able to provide informed consent.
Willing and able to complete all study procedures including MRI tests.
Have had their radial artery pulse checked for the presence of adequate ulnar collateral flow and the absence of any metal or foreign objects in both wrists.
Agree to adhere to the lifestyle considerations

Exclusion

Clinically significant abnormalities on EKG or laboratory testing. This includes CBC and acute care panel (Na, K, Cl, CO2, creatinine, glucose, urea nitrogen).
Any current Axis I diagnosis.
History of neurologic illness or injury with the potential to affect study data interpretation.
History of seizures, other than in childhood and related to fever.
Recent exposure to radiation (i.e., PET from other research) which when combined with this study would be above the allowable limits.
Inability to lie flat on camera bed for at least two hours, including claustrophobia and weight greater than the maximum for the scanner (500 lbs).
HIV Infection.
Pregnancy or breast feeding.
Participants must not have substance use disorder or alcohol use disorder.
Unable to travel to the NIH.
Are unable to have an MRI scan (e.g., because of pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, shrapnel fragments, or metal fragments in the eye.

What this trial measures

  • Total Volume of Distribution120 minutes

    Quantification of JMJ129