Visual Restoration After Stroke Using Focused Ultrasound and Virtual Reality

This study is testing if combining low-intensity focused ultrasound (LIFU) brain stimulation with immersive virtual reality (IVR) therapy can improve vision problems after a stroke. LIFU uses gentle ultrasound waves to stimulate specific parts of the brain, and IVR uses a VR headset for interactive visual exercises. You might be able to join if you are 18 or older, have had an ischemic or hemorrhagic stroke 6 to 24 months ago, and have a visual field defect (like not being able to see part of your vision). The main goal is to see how much your visual field changes from the start of the study until 30 days after treatment ends. The study plans to enroll 28 people, but its current status is unclear.

Study design
This is an interventional study where participants are randomly assigned to receive either active LIFU plus VR, or inactive LIFU plus VR. Neither you nor the researchers will know which group you are in.
What's involved
Active participation in the study lasts 1.5 months, including 9 intervention sessions over 21 days, each lasting about 2.5 hours.
Compensation
Not stated in the trial record.
Follow-up
Your visual field will be measured from enrollment until 30 days after the end of treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06875206

Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

Not Yet Recruiting
NAAges 18+InterventionalTreatment
Duke University
~28 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:Low-intensity focused ultrasoundImmersive virtual realityInactive Low-intensity focused ultrasound

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Visual Field Change
Measured over From enrollment to the 30 days after the end of treatment.
Stroke
Visual Field Defect
Visual Field Defect Following Cerebrovascular Accident
Hemianopia
Quadrantanopia
Occipital Lobe Infarct
Visual Fields Hemianopsia
1 sites across 1 states
North Carolina1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

≥ 18 years old of any gender and race
Clinical ischemic stroke or hemorrhagic (confirmed by CT or MRI) that occurred \>= 6-24 months ago
Partial or complete homonymous hemianopsia on clinical exam

Exclusion

Documented history of severe dementia with or without medication before stroke that affect subject's ability to participate in and be compliant to study protocol
Significant upper motor deficits and the subject cannot do IVR sessions at the baseline
History of seizures
Inability to get a new MRI
Presence of any ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of ultrasonic stimulation on the fetus is unknown); preexisting scalp lesion or wound or bone defect or hemicraniectomy.
Patients will be excluded if they have a previous diagnosis of hemianopsia, a new diagnosis of central retinal ischemic injury, or visual blindness or a history of any other ocular disease.
Concerns about the inability to complete study visits/procedures by the PI.
  • Visual Field ChangeFrom enrollment to the 30 days after the end of treatment.

    Change of the blind area in the visual fields as measured by visual perimetry implemented in a virtual reality (VR) headset