Long-Term Safety of Pirtobrutinib for Leukemia and Lymphoma

This study is looking at the long-term safety of pirtobrutinib, a medication taken by mouth, for people with Chronic Lymphocytic Leukemia or Non-Hodgkin Lymphoma. You can join this study if you have already been part of another Lilly-sponsored study testing pirtobrutinib. The main goal is to track the percentage of participants who experience serious side effects (Grade 3 or higher) from the treatment. This study is designed to follow people who have completed earlier studies to understand the long-term effects of pirtobrutinib. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 787 participants. It is a 'master protocol' that allows people from previous studies to continue receiving treatment or follow-up.
What's involved
Participants will continue to receive treatment with pirtobrutinib or have follow-up visits after completing an earlier study. The study measures side effects from the first dose until 30 days (plus a 7-day window) after the last dose or starting new anticancer therapy.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for side effects from the first dose of pirtobrutinib through 30 days (plus a 7-day window) after the last dose or the start of a new anticancer therapy, whichever comes first.

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NCT06876649

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

Recruiting
PHASE4Ages 18+InterventionalTreatment
Eli Lilly and Company
~787 participants
Updated 2026-03-02 on ClinicalTrials.gov
What's tested:Pirtobrutinib

At a glance

Recruiting sites
32 of 38 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Participants with a Grade ≥3 treatment-emergent AEs
Measured over Time from the Date of the First Dose of Study Intervention (Study Day 1) through 30 Days (+ 7-day window) After the Date of the Last Dose of Study Intervention or The First Date Starting a New Anticancer Therapy, whichever is Earlier
Chronic Lymphocytic Leukemia
Non-Hodgkin Lymphoma
38 sites across 21 states
Japan6
New York5
Florida3
Australia3
United Kingdom3
Italy2
Poland2
Georgia1
  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Are participating in an eligible Lilly sponsored clinical study evaluating pirtobrutinib.
  • Percentage of Participants with a Grade ≥3 treatment-emergent AEsTime from the Date of the First Dose of Study Intervention (Study Day 1) through 30 Days (+ 7-day window) After the Date of the Last Dose of Study Intervention or The First Date Starting a New Anticancer Therapy, whichever is Earlier