Trauma and Cardiometabolic Health in an American Indian Community
This study is looking at the connection between experiences like trauma and resilience, and how your body responds to stress, as well as your current mental and physical health. It involves a behavioral intervention called the Paced Auditory Serial Addition Task, which is a short, challenging task used to measure how your heart, hormones, and inflammation react. Researchers will measure changes in your systolic blood pressure (the top number in a blood pressure reading), diastolic blood pressure (the bottom number), and heart rate during this task compared to when you are resting. The study is open to American Indian individuals aged 18 to 40 who live on or near the Blackfeet reservation and do not have uncontrolled high blood pressure. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 400 participants. It is a cross-sectional study, meaning it looks at data from a group of people at one specific point in time.
- What's involved
- You would participate in two laboratory sessions. These sessions involve providing a blood sample, completing questionnaires, body composition evaluations, and having cardiovascular, neuroendocrine, and inflammatory activity measured during rest and a short psychological task.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Trauma and Cardiometabolic Health in an American Indian Community
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Neha John-Henderson, PhD · PRINCIPAL_INVESTIGATOR · Montana State University
- Annie Ginty, PhD · PRINCIPAL_INVESTIGATOR · Baylor University
- Betty Henderson-Mathews, MA · PRINCIPAL_INVESTIGATOR · Blackfeet Community College
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Changes in systolic blood pressure activity from baseline to task10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
The mean systolic blood pressure (mmHg) will be subtracted from the mean of the task period.
- Changes in diastolic blood pressure activity from baseline to task10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
The mean diastolic blood pressure (mmHg) will be subtracted from the mean of the task period.
- Changes in heart rate activity from baseline to task10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
The mean heart rate (bpm) will be subtracted from the mean of the task period.
- Change in cortisol from baseline to taskBaseline will be subtracted from the peak (15 minutes after task onset, 35 minute task onset)
Salivary samples will be taken to measure cortisol (nmol/L) the mean from the peak stress period will be subtracted from the baseline
- Changes in IL-6 from baseline to taskBaseline will be subtracted from the level 30 minutes after task onset.
IL-6 (pg/mL) measured at baseline will be subtracted from the IL-6 measured post task.
- Pulse wave velocity5 minutes
Pulse wave velocity in m/s will be assessed by dual impedance cardiography as a non-invasive indicator of arterial stiffness. This measure will be derived from the 5 minute baseline period.
- Resting systolic blood pressure10 minutes
Resting systolic blood pressure (mmHg)
- Resting diastolic blood pressure10 minutes
Resting diastolic blood pressure (mmHg)
- Inflammatory and anti-inflammatory cytokines5 minutes
Circulating levels of C-reactive protein, interleukin-6, tumor necrosis factor-a, monocyte chemoattractant protein-1, interleukin-1b, interleukin-10, and adiponectin will be assessed via a blood draw. A composite score will be created.
- Hemoglobin A1c5 minutes
Hemoglobin A1c (nmol/L) will be assessed via blood draw
- Glucose5 minutes
Glucose (nmol/L) will be assessed via blood draw
- Insulin5 minutes
Insulin (mL) will be assessed via blood draw
- Cholesterol5 minutes
Total cholesterol (mg) will be assessed via blood draw
- Low-density lipoprotein5 minutes
Low-density lipoprotein (mg/dL) will be assessed via blood draw
- High-density lipoprotein5 minutes
high-density lipoprotein (mg/dL) will be assessed via blood draw
- Triglycerides5 minutes
Triglycerides (mmol/L) will be assessed via blood draw
- Waist circumference2 minutes
Waist circumference
- Hip circumference2 minutes
Hip circumference
- Depressive symptomology (Hospital Anxiety Depression Questionnaire depression subscale)10 minutes
Hospital Anxiety Depression Questionnaire (depression subscale)
- Depressive symptomology (PHQ-9)10 minutes
PHQ-9
- Anxiety symptomtology5 minutes
Hospital Anxiety Depression Questionnaire (Anxiety subscale)
- Alcohol use10 minutes
Alcohol use will be assessed using the Alcohol Use Identification Test
- Substance use5 minutes
A cumulative score of substance use will be reported by indicating the number of recreational drugs "ever" tried