Tracing How Your Body Uses NAD+ Precursors
This study aims to understand how healthy younger and older adults use two forms of vitamin B3, Nicotinamide Mononucleotide (NMN) and Nicotinamide (NAM), to create NAD+. NAD+ is a natural substance vital for energy and other important cell processes. Researchers want to see how these substances are absorbed, processed, and how they increase NAD+ levels in different parts of the body. You can join if you are a healthy adult, male or female, aged 18-40 or 65 and older, with a body mass index (BMI) between 19 and 35, and no major health issues. Success for this study means understanding how these NAD+ precursors are used by the body, measured by the amount of labeled NAD+ in your blood over 14 days. The current status of this study is unclear.
- Study design
- This is an interventional study planning to enroll 32 healthy adults. Participants will receive either Nicotinamide Mononucleotide (NMN) or Nicotinamide (NAM).
- What's involved
- You will take NMN or NAM by mouth every day for 14 days. Researchers will collect blood, urine, and stool samples during this time.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your NAD+ levels in peripheral blood will be measured during the 14-day study intervention period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Shalender Bhasin, MB, BS · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hosptial
Who to contact
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Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Labelled NAD+ in Peripheral BloodDuring the Study Intervention Period Day 1 through Day 14
Quantify the fraction of peripheral blood. NAD+ containing the stable isotope labelled tracer