Tracing How Your Body Uses NAD+ Precursors

This study aims to understand how healthy younger and older adults use two forms of vitamin B3, Nicotinamide Mononucleotide (NMN) and Nicotinamide (NAM), to create NAD+. NAD+ is a natural substance vital for energy and other important cell processes. Researchers want to see how these substances are absorbed, processed, and how they increase NAD+ levels in different parts of the body. You can join if you are a healthy adult, male or female, aged 18-40 or 65 and older, with a body mass index (BMI) between 19 and 35, and no major health issues. Success for this study means understanding how these NAD+ precursors are used by the body, measured by the amount of labeled NAD+ in your blood over 14 days. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 32 healthy adults. Participants will receive either Nicotinamide Mononucleotide (NMN) or Nicotinamide (NAM).
What's involved
You will take NMN or NAM by mouth every day for 14 days. Researchers will collect blood, urine, and stool samples during this time.
Compensation
Not stated in the trial record.
Follow-up
Your NAD+ levels in peripheral blood will be measured during the 14-day study intervention period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06882096

Tracing the Metabolic Flux of Orally Administered NAD+ Precursors

Recruiting
PHASE1Ages 18+InterventionalBasic science
Metro International Biotech, LLC
~32 participants
Updated 2025-05-06 on ClinicalTrials.gov
What's tested:Nicotinamide Mononucleotide (NMN)Nicotinamide (NAM)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Labelled NAD+ in Peripheral Blood
Measured over During the Study Intervention Period Day 1 through Day 14
Healthy Adults
1 sites across 1 states
Massachusetts1
  • Shalender Bhasin, MB, BS · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hosptial

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Exclusion

Products that contain niacin, nicotinic acid, nicotinamide in any form, other than natural foods
Herbal supplements 2. Treatment with another investigational drug, investigational device, or approved therapy for investigational use within 3 month is prohibited.
  • Labelled NAD+ in Peripheral BloodDuring the Study Intervention Period Day 1 through Day 14

    Quantify the fraction of peripheral blood. NAD+ containing the stable isotope labelled tracer