Radio-KO Radiotherapy for Knee Osteoarthritis Clinical Trial

This study is testing whether low-dose radiotherapy (radiation treatment) can help reduce pain from knee osteoarthritis. You might be able to join if you are 50-100 years old, have been diagnosed with knee osteoarthritis, and receive your primary care at Mayo Clinic in Rochester, MN. Participants will receive either low-dose radiotherapy or a sham treatment (a procedure that looks the same but doesn't deliver radiation). The researchers will measure success by looking at changes in your pain scores (ICOAP Scores) and how often you use pain medication over 6 months. The current status of this study is unclear, but it plans to enroll 128 people.

Study design
This is a single-center, single-blinded, sham-controlled randomized study, meaning participants will be randomly assigned to receive either the active treatment or a sham treatment, and you won't know which one you're getting. It plans to enroll 128 participants.
What's involved
You will receive treatment three times a week for two weeks. You will also complete pain scale questionnaires (ICOAP scores) at the beginning of the study and weekly for six months.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for 6 months after treatment, with pain scores measured at baseline and 6 months, and analgesic use frequency measured at 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06887829

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Recruiting
NAAges 50+InterventionalTreatment
Mayo Clinic
~128 participants
Updated 2026-09-02 on ClinicalTrials.gov
What's tested:Low dose radiotherapySham comparator

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Area Under the Curve (AUC) of ICOAP Scores
Measured over Baseline, 6 months
+1 more outcome measured
Osteoarthritis, Knee

NCT06887829

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic

    Rochester, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Stephen P. Merry, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Family Medicine Research Study Coordinators
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

  • Change in Area Under the Curve (AUC) of ICOAP ScoresBaseline, 6 months

    Change in the Intermittent and Constant Osteoarthritis Pain (ICOAP) outcome scale weekly for six months after intervention analyzed as area under the curve of patients with Kellgren-Lawrence grade 2-3 knee OA.

  • Analgesic use frequency in treatment vs. sham participants6 months

    Differences in the rate of improvement between the 2 groups with analysis to include time points of 2 months and 4 months after intervention.