Radio-KO Radiotherapy for Knee Osteoarthritis Clinical Trial
This study is testing whether low-dose radiotherapy (radiation treatment) can help reduce pain from knee osteoarthritis. You might be able to join if you are 50-100 years old, have been diagnosed with knee osteoarthritis, and receive your primary care at Mayo Clinic in Rochester, MN. Participants will receive either low-dose radiotherapy or a sham treatment (a procedure that looks the same but doesn't deliver radiation). The researchers will measure success by looking at changes in your pain scores (ICOAP Scores) and how often you use pain medication over 6 months. The current status of this study is unclear, but it plans to enroll 128 people.
- Study design
- This is a single-center, single-blinded, sham-controlled randomized study, meaning participants will be randomly assigned to receive either the active treatment or a sham treatment, and you won't know which one you're getting. It plans to enroll 128 participants.
- What's involved
- You will receive treatment three times a week for two weeks. You will also complete pain scale questionnaires (ICOAP scores) at the beginning of the study and weekly for six months.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will be followed for 6 months after treatment, with pain scores measured at baseline and 6 months, and analgesic use frequency measured at 6 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
At a glance
Conditions
NCT06887829
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Mayo Clinic
Rochester, Minnesotastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Stephen P. Merry, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in Area Under the Curve (AUC) of ICOAP ScoresBaseline, 6 months
Change in the Intermittent and Constant Osteoarthritis Pain (ICOAP) outcome scale weekly for six months after intervention analyzed as area under the curve of patients with Kellgren-Lawrence grade 2-3 knee OA.
- Analgesic use frequency in treatment vs. sham participants6 months
Differences in the rate of improvement between the 2 groups with analysis to include time points of 2 months and 4 months after intervention.