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Study of Oral Fluid Testing for Cannabis Use

This study is looking at a new way to measure cannabis use remotely using oral fluid (saliva) tests. Researchers want to see how well these tests work compared to urine tests and self-reported cannabis use. You might be able to join if you are 18-30 years old, use cannabis at least once a week, and have a smartphone or tablet for video calls. The study aims to enroll 200 participants and will measure how long testing takes and how well people follow the testing instructions. The current status of the study is unclear.

Study design
This is an observational study involving 200 participants. It is fully virtual and does not involve new treatments.
What's involved
You would participate in 3 virtual study visits over 3-4 weeks, complete at-home urine and oral fluid tests, and do self-reporting interviews.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints measure testing duration and adherence across 6 days leading up to a Day-21 visit, and on the Day-21 visit itself.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06891235

Study of an Oral Fluid Testing Approach

Recruiting
Not specifiedAges 18–30Observational
Boston Children's Hospital
~200 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Biologic testing for THC

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Testing duration: self-testing
Measured over Across 6 days leading up to the Day-21 visit
+11 more outcomes measured

Conditions

Cannabis Use
Cannabis Intoxication
Cannabis Use Disorder

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Cannabis intoxicationCannabis misuseCannabis Use Disorder

Where it's being run

1 sites across 1 states
Massachusetts1

Who to contact

Lydia A Shrier, MD, MPH
[email protected]
(617) 355-8306
Email the study team

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Eligibility criteria

Inclusion

Age 18 to 30 years
Cannabis use on \>=1x/week in the past 30 days
Ownership of a portable device that is capable of videoconference and videorecording (i.e., smartphone, tablet computer, or laptop computer)
Ability to read and speak English
Availability for duration of the study (3-4 weeks).
To proceed to oral fluid testing, positive result for urinary TCH-COOH

What this trial measures

  • Testing duration: self-testingAcross 6 days leading up to the Day-21 visit

    Duration in minutes of videos of self-testing

  • Testing duration: observed testDay of/During the Day-21 visit

    Duration in minutes of observed self-testing during study visit

  • Oral fluid testing protocol adherence: self-testing completedAcross 6 days leading up to the Day-21 visit

    Number and percent of videos of self-testing completed

  • Oral fluid testing protocol adherence: observed test completedDay of/During the Day-21 visit

    Number and percent of live self-testing completed

  • Oral fluid testing protocol adherence: testing steps performedAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Number and percent of each step of self-testing performed (yes/no)

  • Oral fluid testing protocol adherence: testing steps performed correctlyAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Number and percent of each step of self-testing performed correctly (yes/no)

  • Unreadable test resultsAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Number and percent of oral fluid tests with unreadable results

  • Inconclusive test resultsAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Number and percent of oral fluid tests with inconclusive results

  • Oral fluid test resultsAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Oral fluid test results for delta-9- tetrahydrocannabinol (delta-9-THC) on day of test (negative = non-use / positive = use)

  • Oral fluid acceptabilityDay-21 visit

    Measure of acceptability (usability, likability, burden), 5 items, 5-point Likert-type scale (1, Strongly Disagree to 5, Strongly Agree), with higher score indicating greater acceptability. Benchmark for scale: ≥80% of participants with mean item score ≥4 out of 5

  • Use/Non-use intervals of 4 daysAcross 6 days leading up to the Day-21 visit; Day of/During the Day-21 visit

    Agreement between oral fluid results for 3 consecutive days (any positive = use / all negative = non-use) and self-report on timeline follow-back (TLFB) calendar interview for the same 3 days plus 1 day earlier (any days of use = use / no days of use = non-use). Benchmark: ≥ moderate agreement (Cohen's kappa ≥ 0.6)

  • Use/Non-useDay-21 visit

    Agreement between oral fluid test results (positive/negative) and urine test result (positive/negative). Benchmarks: strong agreement (Cohen's kappa ≥ 0.8) for use; weak agreement (Cohen's kappa \< 0.6) for non-use