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Optimizing Eating Times for Night Shift Workers

This study is looking at how changing when you eat might improve health for night shift nurses and nursing assistants. If you work night shifts, eat for 14 hours or more each day, and have a higher body mass index (BMI), you might be able to join. The study will compare three groups: one that gets healthy lifestyle advice and tracks their food, another that also limits eating to a 10-hour window during the day (Time-Restricted Eating or TRE), and a third group that does TRE but can also have a low-sugar snack during their night shift. Researchers will measure changes in total body fat over 12 months, with the main measurement at 6 months. The study aims to enroll 180 participants, but its current status is unclear.

Study design
This is an interventional study that will randomly assign 180 participants to one of three groups. It is not specified if the study is blinded.
What's involved
You would participate in a 2-week screening, then have health assessments at 3, 6, and 12 months. You would also log all food and beverage intake using an app.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after starting the study interventions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06891352

Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Recruiting
NAAges 18–70InterventionalPrevention
Salk Institute for Biological Studies
~180 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:Dietary MonitoringTime-Restricted Eating (TRE)Time-Restricted Eating with a Low-Glycemic Snack (TRE-LGS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Body Fat Mass (kg)
Measured over Baseline, 3 month, 6 month (primary), and 12 month (follow-up)

Conditions

Night Shift Work
Time Restricted Eating
Overweight
Obesity

Explore related trials

ObesityOverweight

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Emily Manoogian, Ph.D. · PRINCIPAL_INVESTIGATOR · Salk Institute for Biological Studies

Who to contact

UCSD Study Coordinator
[email protected]
858-246-2342
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age: 18-70 years
BMI ≥ 25 kg/m2 (or ≥ 23 kg/m2 for Asian adults)
Own a smartphone (Apple iOS or Android OS)
Baseline eating window ≥ 14 h/day
Night shift nurses and nursing assistants who are working a 12-hour night shift at least 3 days/week.
Have been doing night shift work for at least 3 months.
Patients on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, lipid-modifying drugs (including over-the-counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed
If patients have Type 2 Diabetes, they will be included in the study if A1c is less than 9 and they are not on insulin.

Exclusion

Insufficient dietary logging on the mCC app is defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart.
Type 1 Diabetes or Insulin-dependent Type 2 Diabetes.
Use of sulfonylurea or insulin within the last 3 months (due to unknown safety with TRE)
Use of medications that are known to cause weight loss such as SGLT2 inhibitors and GLP1 receptor agonists)
BMI \> 50 kg/m2
Change in medications that could impact study outcomes within the past 3 months
Change in weight of \>4kg in the past 3 months
Women who are pregnant, breastfeeding, or are trying to become pregnant during the study period. If a participant becomes pregnant during the study, they will be excluded from continuing the study.
Systolic BP greater than 160 mmHg and/or diastolic BP greater than 110 mmHg at rest
Fasting LDL cholesterol greater than 250 mg/dL
Fasting triglycerides greater than 500g/dL
Active tobacco abuse or illicit drug use or history of treatment for alcohol abuse in the past 5 years.
Frequent (more than 4) travel involving a time zone change of more than 3 hours over the 1-year study period
Prolonged leave from work (a continuous month or longer) during the study
Active treatment for inflammatory and/or rheumatologic disease
History of a major adverse cardiovascular event within the past year (acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke/transient ischemic attack)
Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation/atrial flutter are acceptable)
History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (hypothyroidism on a stable dose of thyroid replacement therapy is allowed).
History of adrenal disease in the past 5 years
History of malignancy undergoing active treatment, except non-melanoma skin cancer, in the past 5 years
History of an eating disorder in the past 5 years
History of cirrhosis in the past 5 years
History of stage 4 or 5 chronic kidney disease or dialysis in the past 5 years
History of HIV/AIDs
Currently enrolled in weight-loss or weight-management program
History of surgical intervention for weight management within the past 2 years, or longer if deemed unsafe following review by medical investigators
Uncontrolled psychiatric disorder including prior hospitalization

What this trial measures

  • Total Body Fat Mass (kg)Baseline, 3 month, 6 month (primary), and 12 month (follow-up)

    Total Body Fat Mass (kg) assessed by DXA