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EEG-based Personalized TMS for Post-Traumatic Stress Disorder

This study is testing a treatment called EEG-based personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD). eTMS uses magnetic pulses to stimulate specific brain areas, with the treatment tailored to your individual brain activity measured by an Electroencephalogram (EEG). We want to see if eTMS can reduce PTSD symptoms. You might be able to join if you are a U.S. military veteran or first responder between 22 and 65 years old, and have been diagnosed with PTSD for at least six months. The study aims to enroll 110 participants, and the current status is unclear.

Study design
This is a randomized, sham-controlled study, meaning some participants will receive the active eTMS treatment and others a sham (inactive) treatment. The study plans to enroll 110 participants.
What's involved
You would have an EEG recording, followed by 15 office visits over 21-28 days, with two eTMS treatment sessions during each visit.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be measured at the beginning of the study and again between 21-28 days after starting treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06892028

EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Recruiting
NAAges 22–65InterventionalTreatment
Wave Neuroscience
~110 participants
Updated 2025-03-24 on ClinicalTrials.gov
What's tested:EEG-based personalized TMSSham Comparator

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Improvement in PTSD Symptoms as Measured by Drop in Score on the PTSD Checklist for DSM-5 (PCL-5)
Measured over Baseline and Final Measure, between 21-28 Days

Conditions

Stress Disorder, Post Traumatic

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

2 sites across 1 states
Ohio2

Study leadership

  • Bill Phillips, PhD · PRINCIPAL_INVESTIGATOR · Wave Neuroscience, Inc.

Who to contact

Matthew Sherwood, PhD
[email protected]
937-775-2342
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Willing and able to consent to participate in the study via signed Informed Consent
Age 22 - 65 years
Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS).
Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit
Veterans Administration PCL-5 cut point score of 31 or above
Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel)

Exclusion

Uncontrolled medical, psychological or neurological condition
Pregnant, or female unwilling to use effective birth control during the course of the trial
Metal objects in the head
Past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck
Current participation in any interventional research protocol
History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)
History of stroke or intracranial lesion or increased intracranial pressure
History of epilepsy of seizure
Family history of epilepsy or seizure in 1st degree relative
An elevated risk of suicide or violence to others

What this trial measures

  • Improvement in PTSD Symptoms as Measured by Drop in Score on the PTSD Checklist for DSM-5 (PCL-5)Baseline and Final Measure, between 21-28 Days

    The Post Traumatic Stress Disorder (PTSD) Checklist for Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. (DSM-5), commonly referred to as PCL-5, is a 20-item self-report measure that assesses the 20 DSM-5 symptoms of PTSD. It is used to monitor symptom change during and after treatment. Each item is scored from 0 to 5 as the participant's estimate of the severity of the symptom (0 = Not at all, 1=A little bit, 2 = Moderately, 3 = Quite a bit, 4 = Extremely). The final score range is between 0-80. A lower score is considered better than a higher score.