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Breastmilk in Response to a Bout of Exercise

This observational study is looking at how a mother's exercise after giving birth affects her breastmilk. Researchers want to understand if exercise changes breastmilk in a way that benefits the baby's health, particularly in preventing conditions like childhood obesity and diabetes. They will measure the concentration of exosomes (tiny sacs that carry messages between cells) in breastmilk at one month after birth. You may be able to join if you are a woman between 18 and 45 years old. The study is currently unclear on its recruitment status and plans to enroll 60 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving any specific treatment. It aims to enroll 60 women.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Breastmilk exosome concentration will be measured at 1 month.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06892483

Breastmilk in Response to a Bout of Exercise

Recruiting
Not specifiedAges 18–45Observational
Mayo Clinic
~60 participants
Updated 2026-06-24 on ClinicalTrials.gov
What's tested:Pre-Pregnancy BMI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Breastmilk Exosome Concentration
Measured over 1 month

Conditions

Infant Development
Obesity, Childhood
Diabetes, Childhood-Onset

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Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic

    Rochester, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Mark Pataky, Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Linda Szymanski, M.D., Ph.D.
[email protected]
5072668539
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Exclusion

Active coronary artery disease or heart failure.
Participation in a structured exercise program ≥ 1 day/week in the "inactive" subcohort or \< 3 days per week in the "active" subcohort.
A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples:
Abnormal liver function test results (Transaminase \>2 times the upper limit of normal
Abnormal renal function test results (calculated GFR \<60 mL/min/1.73m2);
If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study
Uncontrolled thyroid disease (TSH undetectable or \>10 mlU/L); testing required within three months prior to admission for subjects with a goiter, positive antibodies, or who are on thyroid hormone replacement, and within one year otherwise
Abuse of alcohol or recreational drugs
Active tobacco smoking within the past 3 months
Infectious process not anticipated to resolve prior to study procedures (e.g. meningitis, pneumonia, osteomyelitis).
Uncontrolled arterial hypertension (Resting diastolic blood pressure \>90 mmHg and/or systolic blood pressure \>160 mmHg) at the time of screening.
A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol
Active pregnancy
Restrictions on Use of Other Drugs or Treatments:
Any other medication believed to be a contraindication to the subject's participation.

What this trial measures

  • Breastmilk Exosome Concentration1 month

    The molecules in small extracellular vesicles (exosomes) can transmit information between cells throughout the body. A bout of exercise induces a robust release of exosomes in the plasma with unique molecular cargo. Exosomes are also present in breastmilk, and there is evidence that breastmilk exosomes can evade degradation in the infant gut and can thus transmit molecular information from mother to infant. Though maternal exercise is viewed as beneficial for the breastfeeding infant, the molecular mechanisms of how this occurs remain unknown. The primary objective of this trial will be to determine if a bout of maternal exercise increases the release exosomes in breastmilk. The investigators will measure breastmilk exosome concentration using nano particle tracking.