Understanding Ketogenic Diet and Cholesterol Levels

This study aims to understand why some normal-weight people develop high cholesterol (hypercholesterolemia) when following a ketogenic diet. Researchers will provide all meals for participants, who will follow either a ketogenic diet or a control diet for four weeks each. The main goal is to measure how quickly certain cholesterol-carrying particles (VLDL-ApoB100) are produced after each diet period. You may be able to join if you are between 18 and 39 years old, have a healthy weight (BMI between 18.5 and 25.0), and have normal cholesterol and blood sugar levels. The study is currently unclear about its recruitment status, but it plans to enroll 100 participants.

Study design
This is an interventional study planning to enroll 100 participants. It involves a randomized crossover design where participants will try both the ketogenic and control diets.
What's involved
Participants will follow a ketogenic diet for 4 weeks and a control diet for 4 weeks, with all food provided. There will be a 4-week break between the two diet periods.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken immediately after each 4-week diet period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06894004

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Recruiting
NAAges 18–39InterventionalBasic science
Washington University School of Medicine
~100 participants
Updated 2026-03-23 on ClinicalTrials.gov
What's tested:Ketogenic DietControl Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
VLDL-ApoB100 production rate
Measured over Immediately after the 4-week ketogenic diet intervention period and immediately after the 4-week control diet intervention period.
Hypercholesterolemia and Hyperlipidemia
1 sites across 1 states
Missouri1
  • Max C Petersen, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

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  • VLDL-ApoB100 production rateImmediately after the 4-week ketogenic diet intervention period and immediately after the 4-week control diet intervention period.

    Determined by using plasma and VLDL-ApoB100 leucine isotopic enrichment and compartmental modeling