Understanding Ketogenic Diet and Cholesterol Levels
This study aims to understand why some normal-weight people develop high cholesterol (hypercholesterolemia) when following a ketogenic diet. Researchers will provide all meals for participants, who will follow either a ketogenic diet or a control diet for four weeks each. The main goal is to measure how quickly certain cholesterol-carrying particles (VLDL-ApoB100) are produced after each diet period. You may be able to join if you are between 18 and 39 years old, have a healthy weight (BMI between 18.5 and 25.0), and have normal cholesterol and blood sugar levels. The study is currently unclear about its recruitment status, but it plans to enroll 100 participants.
- Study design
- This is an interventional study planning to enroll 100 participants. It involves a randomized crossover design where participants will try both the ketogenic and control diets.
- What's involved
- Participants will follow a ketogenic diet for 4 weeks and a control diet for 4 weeks, with all food provided. There will be a 4-week break between the two diet periods.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken immediately after each 4-week diet period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Max C Petersen, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
Who to contact
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What this trial measures
- VLDL-ApoB100 production rateImmediately after the 4-week ketogenic diet intervention period and immediately after the 4-week control diet intervention period.
Determined by using plasma and VLDL-ApoB100 leucine isotopic enrichment and compartmental modeling