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ADHERE-LPV Study: Improving Lung-Protective Ventilation

This study, called ADHERE-LPV, is looking at ways to improve how hospitals use lung-protective ventilation (LPV) for patients on breathing machines. Researchers are testing a new ventilator order system within hospital electronic health records (EHRs) to make it easier for doctors to choose settings that protect the lungs. The study aims to see if this new system leads to more patients receiving LPV within 4 hours of starting ventilation. You might be able to join if you are 18 or older and need mechanical ventilation. The study is currently unclear on its recruitment status and plans to enroll about 1125 people across 10 hospitals.

Study design
This is a cluster randomized study involving 10 hospitals, divided into groups based on their size. Hospitals will either use the new ventilator order system or their current system.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, lung-protective ventilation, is measured at 4 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06895148

ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation

Recruiting
NAAges 18+InterventionalHealth services
University of Minnesota
~1,125 participants
Updated 2026-07-09 on ClinicalTrials.gov
What's tested:New ventilatorcontrol ventilator

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
lung-protective ventilation
Measured over 4 hours

Conditions

Ventilation

Explore related trials

Mechanical Ventilation

Where it's being run

1 sites across 1 states
Minnesota1

Who to contact

Nick Ingraham, MD, MS
[email protected]
(612) 624-0999
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Aged 18 and over
Requires mechanical ventilation

Exclusion

The patient opted out of research
The mode ordered does not require a set tidal volume
Requires ECMO prior to ICU admission
Data during the use of ECMO
Hospitalization was for an elective surgery
The duration of mechanical ventilation was less than 12 hours (these are not the patients that would benefit from LPV)
Admission code documentation of Do Not Intubate. While rare, in situations where a patient was intubated but whose preferences are contradictory to the current care, mechanical ventilation is managed differently while undergoing goals of care conversations.
Height was documented as less than 4 feet given the PBW formula was not validated below this height.

What this trial measures

  • lung-protective ventilation4 hours

    The primary outcome is a binary indicator of lung-protective ventilation (ventilator set at ≤ 8 cc/kg) at the first documented set tidal volume after 4 hours.