This study is looking at how blood flow in your heart's arteries changes when a medication called nitroglycerin is given directly into them. It's for people who have angina (chest pain) but don't have major blockages in their heart arteries, a condition called ANOCA or INOCA. Researchers will perform a test called coronary reactivity testing (CRT) to measure blood flow before and after giving nitroglycerin. The main goal is to see how nitroglycerin affects the coronary flow reserve (CFR), which is a measure of how well your heart arteries can increase blood flow. About 50 people will participate in this study. You can join if you are 18 or older, have ANOCA or INOCA, and have clinical suspicion of angina. The study aims to understand if nitroglycerin can improve blood flow in these patients.

Study design

This is a single-arm, multi-center study, meaning all participants will receive the same intervention. Approximately 50 patients will be enrolled.

What's involved

You will undergo coronary angiography and coronary reactivity testing, first without and then with intracoronary nitroglycerin, during a cardiac catheterization procedure.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome, CFR assessment, is measured during the procedure (Intra op).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.