Back to search results

Understanding Brain Injury After Heart Surgery in Children

This study is looking at children under 18 who are having heart surgery using a heart-lung machine at Boston Children's Hospital. Researchers want to understand if certain proteins in the blood, called Tau and GFAP, are connected to brain injury after surgery. They will collect discarded blood samples before and after surgery from routine lab tests. The main goal is to describe any brain impairment that happens within 24 hours after surgery. This is an observational study, meaning researchers are just watching and collecting information, not giving any new treatments. The study aims to include 100 patients. The current recruitment status is unclear.

Study design
This is an observational study that plans to include 100 participants. Researchers will collect information without giving any new treatments.
What's involved
Discarded blood samples will be collected from your routine clinical lab tests before and after surgery.
Compensation
Not stated in the trial record.
Follow-up
Researchers will look for brain impairment at 24 hours after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06899971

The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery

Not Yet Recruiting
Not specifiedUp to 18Observational
Boston Children's Hospital
~100 participants
Updated 2026-03-17 on ClinicalTrials.gov
What's tested:Collecting discarded blood samples

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterization of postoperative neurological impairment
Measured over 24 hours following surgery

Conditions

Cardiac Surgery Requiring Cardiopulmonary Bypass
Brain Injury
Congenital Heart Defect

Explore related trials

Heart Malformation

Where it's being run

1 sites across 1 states
Massachusetts1

Who to contact

Koichi Yuki, MD
[email protected]
617-355-6115
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

less than 18 years old
undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital

Exclusion

undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
patient in a moribund condition American Society of Anesthesiology (ASA 5)
patient with a hematological and/or oncological disease
Jehovah witnesses
patient on preoperative mechanical ventilation

What this trial measures

  • Characterization of postoperative neurological impairment24 hours following surgery

    Understand the correlation between measured proinflammatory cytokines and several proteins that are highly expressed in brain cells with postoperative neurological status.