Pilot Study: Nimodipine for Alcohol Use Disorder
This pilot study is looking at how a medication called nimodipine affects alcohol drinking in adults with Alcohol Use Disorder (AUD). Nimodipine is given orally (by mouth) several times over 18 hours. Researchers want to see how many drinks you consume, your alcohol craving, and any stimulation effects during a lab session. To join, you must be between 21 and 50 years old, able to read English, and meet criteria for at least moderate AUD. This study is currently recruiting 5 participants who are not actively seeking treatment for their drinking. The study's status is unclear.
- Study design
- This is an open-label (meaning you and the researchers know what treatment you're receiving) interventional pilot study, planning to enroll 5 participants.
- What's involved
- You would stay overnight at the hospital, receive nimodipine every six hours for 18 hours, and have EEG (brain wave) data collected. You will then participate in an alcohol drinking session.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcomes, such as number of drinks consumed and alcohol craving, are measured during one lab session (Day 1).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Pilot Study: Effects of Nimodipine on Alcohol Drinking
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Suchitra Krishnan-Sarin · PRINCIPAL_INVESTIGATOR · Yale University School of Medicine, Dept of Psychiatry
Who to contact
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What this trial measures
- Number of drinks consumedLab Session 1 (Day 1)
Total number of drinks (out of 12) that were consumed during the alcohol drinking paradigm (ADP) session.
- Alcohol Craving using Yale Craving ScaleLab Session 1 (Day 1)
Craving for alcohol based on Yale Craving Scale, scores ranging from 0-112 mm on a visual analog scale, with higher measurements indicating higher craving.
- Stimulation EffectLab Session 1 (Day 1)
Stimulation effect collected using the Biphasic Alcohol Effect Scale. Brief Biphasic Alcohol Effects Scale-Stimulation subscale, measuring stimulation effects of alcohol on an 11-point rating scale from 0=Not at All to 10=Extremely, total scores ranging from 0 - 30, with higher measurements indicating higher stimulation.
- Sedation EffectLab Session 1 (Day 1)
Stimulation effect collected using the Biphasic Alcohol Effect Scale. Brief Biphasic Alcohol Effects Scale-Sedation subscale, measuring sedation effects of alcohol on Day 7, 6 items, 11-point rating scale from 0=Not at All to 10=Extremely, total scores ranging from 0 - 30, with higher measurements indicating higher sedation.