Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

This study is testing a new way to treat soft tissue sarcoma (a type of cancer that grows in soft tissues like muscle or fat) in your arm, leg, or trunk (chest, abdomen, and pelvis). It uses a shorter course of radiation therapy called Hypofractionated Radiation Therapy (HFRT) given over 5 days before surgery. The goal is to treat the cancer and prevent it from spreading, while also protecting healthy tissue. Researchers will be looking at how safe HFRT is and any early side effects. You may be able to join if you are 18 or older, have a confirmed soft tissue sarcoma in an arm, leg, or trunk, and are healthy enough for radiation and surgery. This study plans to enroll 40 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 40 participants.
What's involved
Active participation in the study will involve about 12 visits. These visits are completed once you have a 6-month post-operation visit.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, HFRT Safety, is measured at 6 months.

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NCT06905132

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

Recruiting
PHASE2Ages 18+InterventionalTreatment
Medical University of South Carolina
~40 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:Hypofractionated Radiation Therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
HFRT Safety
Measured over 6 months
Soft Tissue Sarcoma
1 sites across 1 states
South Carolina1
  • Jennifer Harper, MD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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Eligibility criteria

Inclusion

Willingness and provision of informed consent via signed and dated copy.
Histologically confirmed STS of extremity or trunk.
Male or female, aged greater than or equal to 18 years old
ECOG performance status 0-3
Meets screening criteria for receipt of radiotherapy.
Deemed eligible for wide local excision.
Patient and/or physician identified possible barriers to receiving a 5-week course of conventionally fractionated preoperative radiotherapy. Potential barriers include but are not limited to concern for local progression that could precluded or complicate limb sparing surgery, concern for distant progression that could result in patient being non-operative, financial and/or physical burden of travel for daily treatments, financial burden of time away from work or caregiving.

Exclusion

Distant metastatic disease
Prior radiation therapy in the proposed treatment area
Simultaneous treatment of another malignancy
Women who are pregnant or plan to become pregnant during the period of radiation therapy
Planned concurrent administration of chemotherapy and radiation therapy
  • HFRT Safety6 months

    Evaluate the safety of 5-day HFRT as measured by the rates of major wound complications occurring within 120 days of surgery.