Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

{ "Validating a Neck Pain Treatment Rule", "This study aims to improve neck pain treatment by testing a method to identify people most likely to benefit from a specific physical therapy technique called cervical spine thrust joint manipulation (a quick, gentle movement of the neck joints). We are looking for 160 adults, aged 18-70, who have neck pain, with or without arm symptoms, and a certain level of disability and pain. Participants will receive either cervical manipulation or low-grade mobilizations (gentle neck movements), followed by exercises. The main goal is to see if those identified by the method as likely responders to manipulation show greater improvement in their neck disability after 6 months. We also want to see if this approach reduces healthcare costs.", "design": "This is a randomized clinical trial involving 160 participants. You would be assigned by chance to one of two treatment groups.", "commitments": "You would receive 2 sessions of either cervical manipulation or mobilization, followed by 3 sessions of exercises. You will have follow-up assessments at one week, 4 weeks, 3 months, and 6 months.", "compensation": "Not stated in the trial record.", "follow_up": "Participants will be followed for 6 months after treatment to assess both short-term and long-term effects.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06906107

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

Recruiting
NAAges 18–70InterventionalTreatment
Baylor University
~160 participants
Updated 2026-04-14 on ClinicalTrials.gov
What's tested:Cervical ManipulationExerciseMobilization

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Neck Disability Index
Measured over 6 months
Neck Pain Musculoskeletal
Neck Pain Treatment
Cervicalgia
4 sites across 4 states
Minnesota1
New York1
Texas1
Wisconsin1
  • Jessica T Feda, DSc · PRINCIPAL_INVESTIGATOR · Baylor University
  • Emilio J Puentedura, PhD · STUDY_DIRECTOR · Baylor University

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Eligibility criteria

Inclusion

Ages 18 to 70
Primary complaint of neck pain with or without unilateral upper extremity symptoms
Neck Disability Index (NDI) score of 10 or greater
Numeric Pain Rating Scale score of 2 or greater

Exclusion

History of whiplash injury within the past 6 weeks
Diagnosis of cervical spinal stenosis
Bilateral upper extremity symptoms
Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumor, fracture, rheumatoid arthritis, osteoporosis, severe atherosclerosis, dizziness, diplopia, drop attacks, bilateral numbness, nausea, prolonged history of steroid use)
Evidence of central nervous system involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman's and/or Babinski reflexes)
Two or more positive neurological signs consistent with significant nerve root compression, including any two of the following:
Prior neck surgery
Current pregnancy, pregnancy within 6 months, or currently lactating
Pending legal action pertaining to their neck pain
Currently receiving manual therapy treatment for neck pain through chiropractic or physical therapy care
Inability to read English at the 8th grade reading level
Inability to legally provide informed consent for any other reason
Inability to comply with the treatment and follow-up schedule
  • Neck Disability Index6 months

    10-item patient self-report measure of perceived disability. Each question is scored from 0 to 5. Minimum value of 0 and maximum value of 50. Higher scores indicate worse disability and a poorer outcome.