Long-term Safety of ARD103 CAR-T Cell Therapy for AML and MDS

This observational study is looking at the long-term safety of ARD103 CAR-T cell therapies in people who have acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) and have already received this treatment in a previous study. The study aims to track any side effects (adverse events or AEs), serious side effects (SAEs), and side effects of special interest (AESIs) related to ARD103 for up to 15 years. You can join if you have R/R AML or MDS and have previously received ARD103 CAR-T cell therapy. This study is currently unclear on its recruitment status and plans to enroll 49 participants.

Study design
This is an observational study with no specified phase, planning to enroll 49 participants. It is a long-term follow-up study.
What's involved
You would be monitored for up to 15 years after receiving ARD103, with monitoring continuing for 13 years after a 24-month interventional study period.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 15 years to monitor the incidence and duration of side effects related to ARD103 treatment.

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NCT06906380

A Long-term Follow-up Study of Patients With ARD103 CAR-T Cell Therapies

Not Yet Recruiting
Not specifiedAll AgesObservational
ARCE Therapeutics, Inc.
~49 participants
Updated 2025-12-08 on ClinicalTrials.gov
What's tested:Non interventional study

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The incidence and duration of AEs, SAEs, and AESIs related to ARD103 treatment.
Measured over 15 years
Acute Myeloid Leukemia, in Relapse
Acute Myeloid Leukemia, in Relapsed or Refractory
MDS (Myelodysplastic Syndrome)
3 sites across 2 states
North Carolina2
Texas1

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Eligibility criteria

Inclusion

The participant has R/R AML or MDS and has previously received ARD103 CAR-T cell therapies in the parent study.
The participant is able to understand and comply with protocol-required study procedures and has provided a written informed consent document.
  • The incidence and duration of AEs, SAEs, and AESIs related to ARD103 treatment.15 years

    The number and percentages of participants experiencing TEAEs will be tabulated. Serious TEAEs will be summarized and AESIs will be summarized.