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Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease with Deep Brain Stimulation

This study is looking at how Deep Brain Stimulation (DBS) affects walking patterns in people with Parkinson's Disease. Researchers want to see if DBS helps people adapt their walking on a special treadmill. They will measure changes in step length after one hour. You might be able to join if you are 18 to 80 years old, have a Parkinson's diagnosis, and have had stable DBS for at least six months. The study is currently unclear on its recruitment status and plans to enroll 60 participants.

Study design
This is an interventional study with 60 planned participants. It will compare walking with DBS turned on versus DBS turned off.
What's involved
You will walk on a split-belt treadmill under different conditions while off your Parkinson's medication. This will involve baseline, adaptation, and post-adaptation walking.
Compensation
Not stated in the trial record.
Follow-up
Your step length will be measured at 1 hour to assess adaptation and after-effects.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06911229

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Recruiting
NAAges 18–80InterventionalBasic science
University of Florida
~60 participants
Updated 2026-07-15 on ClinicalTrials.gov
What's tested:Deep Brain Stimulation (DBS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Step length rate of adaptation
Measured over 1 hour
+2 more outcomes measured

Conditions

Parkinson Disease

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Parkinson Disease

NCT06911229

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Florida

    Gainesville, Floridano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Julia Choi, Ph.D.
[email protected]
3522941720
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
Age between 18 - 80 years old per the FDA data sheet for PD DBS;
no dementia according to the clinical diagnostic criteria for PD dementia;
ambulatory without the use of walking aids, or another person's assistance.

Exclusion

other previous neurological surgery;
suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

What this trial measures

  • Step length rate of adaptation1 hour

    The rate of adaptation in step length asymmetry is estimated by fitting an exponential decay function to step length asymmetry over the first 100 strides in adaptation.

  • Step length magnitude of adaptation1 hour

    The magnitude of adaptation in step length asymmetry is calculated as the mean difference in step length asymmetry between early and late adaptation.

  • Step length after-effects1 hour

    The after-effect in step length asymmetry is calculated as the mean difference in step length asymmetry between baseline and early post-adaptation.