Knee Osteoarthritis Study: Ibuprofen and Dextrose Prolotherapy
This study is looking at how effective and safe it is to combine Ibuprofen (a common anti-inflammatory medicine) with dextrose prolotherapy (DPT) injections for treating knee osteoarthritis (OA). Researchers want to see if taking Ibuprofen around the time of DPT injections helps more than DPT injections with a placebo (an inactive substance). You might be able to join if you are between 45 and 75 years old, have knee OA, and are a DoD Healthcare beneficiary at DGMC. The study will measure changes in your knee pain and function using questionnaires over 12 weeks to see if the treatments are successful. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 68 participants. Participants will be divided into groups, with one group receiving Ibuprofen and DPT injections, and the other receiving a placebo and DPT injections.
- What's involved
- Participants will receive DPT injections every 3-5 weeks for a total of 3 times. On the day of each injection, they will take either Ibuprofen or a placebo for 7 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your knee pain and function will be measured from enrollment until the end of treatment at 12 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis
At a glance
Conditions
NCT06911359
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
David Grant USAF Medical Center
Travis AFB, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Alexander R Kim, MD · PRINCIPAL_INVESTIGATOR · David Grant USAF Medical Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Want this trial checked against your situation?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Change in Knee Injury in Osteoarthritis (KOOS) questionnaire scoresFrom enrollment to the end of treatment at 12 weeks
The KOOS questionnaire consist of a total of 23 items divided (unequally) among 5 subscales. The subscales include pain (5 items), symptoms (4 items), activities of daily living (ADL) (9 items), sport/recreation (3 items), and quality of life (QoL) (2 items). Each item is scored on a scale of 0-4. Zero is assigned to "never", "none," and "not at all" responses. Four is assigned to "always", "extreme," "totally," and "constantly" responses. Calculate mean scores for each subscale by adding the scores for each item (in the subscale) then dividing it by the total number of items (in the subscale). Then multiply the calculated mean scores (for each subscale) by 100, divide it by 4, then subtract it from 100. Total subscale scores range from 0 -100. 0 indicates extreme problems and 100 indicates no problems.
- Change in Numeric Pain Rating Scale (NPRS) scoresFrom enrollment to the end of treatment at 12 weeks
The NPRS is a 1-item questionnaire assessing pain severity using a number which describes the level of knee pain over the last 24 hours. Participants are to put an "X" on a linear scale from 0-10. Zero (0) is no pain and 10 is the worst possible pain.