Pediatric Neuroimaging Study

This study is looking at how the brain changes during puberty in healthy children. Researchers want to understand these changes by taking special brain scans. They aim to collect high-quality brain imaging data using two advanced MRI techniques, BMC-mcDESPOT and C-NODDI, from up to 30 girls and 30 boys. You can join if you are a healthy child between 9 and 14 years old, and your parent or guardian agrees. The main goal is to see if it's possible to get these detailed brain scans and also measure puberty and body changes in children this age. The study is currently unclear on its recruitment status.

Study design: This is an observational study, meaning researchers will observe participants without giving any interventions. It plans to enroll 80 participants.
What's involved: You would have 2 clinic visits, each lasting up to 4 hours. These visits include a physical exam, blood tests, a mental health questionnaire, and a practice MRI scan.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint is measured at 1 year of recruitment, but it's not specified if participants have follow-up after their visits.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Pediatric Neuroimaging

Recruiting

Not specifiedAges 9–14Observational

National Institute on Aging (NIA)

~80 participants

Updated 2026-05-15 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

The primary endpoint is to obtain high-quality BMC-mcDESPOT and C-NODDI MRI data from up to 30 female and up to 30 male participants between 9 and 14 years old.

Measured over 1 year of recruitment

Conditions

Neurogimaging

Where it's being run

1 sites across 1 states

Maryland1

Study leadership

Tina Gupta, M.D. · PRINCIPAL_INVESTIGATOR · National Institute on Aging (NIA)

Who to contact

Tina Gupta, M.D.

[email protected]

(301) 451-0481

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Stated willingness to comply with all study procedures and availability for the duration of the study.

Male or female, 9 to 14 years of age.

In good general health

Ability of parent/guardian to understand and the willingness to sign a written informed consent document.

Ability of participant to participate in the assent process and willingness to sign a written informed assent document.

Exclusion

Any known brain abnormalities (e.g. tumor, periventricular leukomalacia, microcephaly) or history of medical conditions known to affect cerebral micro or macro-structural integrity (e.g., epilepsy, history of stroke, head injury with a loss of consciousness of one hour or more).

History neurodevelopmental delay or disorder, learning disability, intellectual disability (formerly referred to as mental retardation), autism spectrum disorders, and attention deficit/hyperactivity disorder (ADHD)), as evaluated history, physical and by the SDQ, and if indicated, the KSADS

History of psychiatric disorder as evaluated by history and the SDQ, and if indicated, the KSADS.

History of prematurity (\< 32 weeks gestational age).

History of endocrine abnormalities, including diagnosed disorders of thyroid, growth, and precocious or delayed puberty

History of major medical conditions or chronic medical conditions. Examples include neurological disorders, medical or genetic conditions with associated neurological manifestations, malnutrition, conditions raising risk of micronutrient or macronutrient deficiencies (e.g. inflammatory bowel disease), untreated chronic anemia, cardiovascular disease, significant lung disease (e.g. bronchiectasis), significant liver disease, significant kidney disease, significant autoimmune condition, and chronic infections (e.g. HIV, hepatitis B).

Pregnancy.

Not eligible to have an MRI as per the MRI eligibility form and the safety standards of the NIA 3T MRI center.

Presence of hardware (e.g. orthodontic braces) that may interfere with MRI data quality.

Any other condition which in the investigator s opinion may adversely affect the subject s ability to complete the study or its measures or which may pose significant risk to the subject.

What this trial measures

The primary endpoint is to obtain high-quality BMC-mcDESPOT and C-NODDI MRI data from up to 30 female and up to 30 male participants between 9 and 14 years old.1 year of recruitment
Number of participants with high-quality BMC-mcDESPOT and C-NODDI MRI data

Trialytics