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NCT06913985

Trajectory Study: Predicting Cardiometabolic Health in Adolescents and Young Adults Based on Childhood Fitness, Sleep, and Diet

Enrolling by Invitation
Not specifiedAges 13–21Observational
Arkansas Children's Hospital Research Institute
~250 participants
Updated 2025-07-02 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Composite score of cardiometabolic health status.
Measured over Baseline assessment in childhood (ages 7-10) and follow-up assessment during adolescence or early adulthood (ages 13-21)

Conditions

Cardiometabolic Health

Explore related trials

Cardiometabolic Health

Where it's being run

2 sites across 1 states
Arkansas2

Study leadership

  • Elisabet Borsheim, Ph.D · PRINCIPAL_INVESTIGATOR · Arkansas Children's Research Institute

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ages 13 to 21 years.
Boys or girls.
All ethnicities.
All BMIs.
Previous participation in the Arkansas Active Kids study and the MI Energy study.
Participants who previously agreed to be contacted for future research at ACNC.
Participants who agree to the use of their previously collected information and samples from the AAK or MI Energy studies for the follow-up study.

Exclusion

Asthma that requires daily use of inhalers to keep symptoms under control.
Asthma that requires use of rescue inhalers (e.g., albuterol) \>2 days per week.
Exercise-induced asthma.
Autism spectrum disorder (e.g., Autistic disorder, Rett disorder, Asperger disorder, childhood disintegrative disorder, pervasive developmental disorder not otherwise specified (PDD-NOS).
Neurological disorders (e.g. epilepsy or seizures).
Cancer.
Hormonal disease (e.g., hypothyroidism and growth hormone deficiency).
Autoimmune diseases (e.g., lupus, thyroiditis, juvenile idiopathic arthritis).
Bleeding disorders (e.g., hemophilia).
Chronic infections (e.g., HIV, hepatitis B, hepatitis C).
Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest.
Pregnancy (verbal assessment).

What this trial measures

  • Composite score of cardiometabolic health status.Baseline assessment in childhood (ages 7-10) and follow-up assessment during adolescence or early adulthood (ages 13-21)

    This composite outcome evaluates cardiometabolic health across two time points (pre-/early-adolescence and adolescence/early adulthood). It is calculated as the mean of z-scores for: fasting triglycerides and total cholesterol/HDL ratio (from fasting blood samples), HOMA2-IR (from fasting glucose and insulin), systolic blood pressure (automated sphygmomanometer), fat mass index \[DXA-derived fat mass (kg)/height²\], and inverse peak oxygen uptake (measured via graded exercise test with indirect calorimetry). The composite provides an overall measure of cardiometabolic health status. The goal is to assess whether childhood aerobic fitness, sleep quality, and diet quality independently predict this score, controlling for adiposity \[DXA-derived fat mass index (kg/m²)\].