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Acupuncture for Period Loss Due to Chemotherapy

This study is exploring whether acupuncture can help women who have lost their periods (amenorrhea) because of chemotherapy for cancer. Researchers want to see if it's practical to offer acupuncture and how many people will join and complete the study. They will also look at how acupuncture affects the return of your menstrual cycle, as well as symptoms and your quality of life. You may be able to join if you are a woman between 15 and 40, speak English, have a history of certain cancers, had regular periods before diagnosis, and finished chemotherapy within the last year. The study aims to enroll 60 participants.

Study design
This interventional study plans to enroll 60 participants. It compares acupuncture treatment to a group that receives no acupuncture initially but can get it later.
What's involved
If you are in the acupuncture group, you would receive 12 acupuncture treatments over 12 weeks, with one treatment per week.
Compensation
Not stated in the trial record.
Follow-up
The study measures adherence to acupuncture treatment for up to 16 weeks, but no specific follow-up period after treatment is mentioned.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06915116

Acupuncture for People Experiencing Period Loss Due to Chemotherapy

Recruiting
PHASE2Ages 15–40InterventionalTreatment
Memorial Sloan Kettering Cancer Center
~60 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:AcupunctureNo Acupuncture

At a glance

Recruiting sites
7 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Enrollment rate
Measured over 1 year
+1 more outcome measured

Conditions

Cancer
Period Problem

Explore related trials

AmenorrheaHematologic NeoplasmMalignant Neoplasm

Where it's being run

7 sites across 2 states
New York4
New Jersey3

Study leadership

  • Jun Mao, MD, MSCE · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

Jun Mao, MD, MSCE
[email protected]
646-608-8553
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

English speaking woman between the ages of 15 and 40
History of stage I, II, or III cancer OR stage IV or unstaged hematologic malignancy (e.g. lymphoma, leukemia, myeloma) that is stable, as assessed by care team
Premenopausal status with regular menstruation at the time of diagnosis by patient report
Completed cytotoxic chemotherapy within the past year
Premenopausal status with regular menstruation at the time of diagnosis by patient report for females ages 18 or older
Report cessation of menses during or after chemotherapy and have not experienced menses recovery at the time of enrollment.
Have reached menarche prior to therapy or during therapy for females between 15 and 17 years old
Patient meets at least one of the following:
Reports cessation of menses during or after chemotherapy and have not experienced menses recovery at the time of enrollment and has been without menses for at least 3 months 64 following the completion of cytotoxic chemotherapy; OR
Is receiving ovarian suppression therapy (e.g., leuprolide \[Lupron\] or goserelin \[Zoladex\]) or hormonal contraceptive drugs, regardless of menstrual status, and report persistent (≥3 months), moderate-to- severe menopause-related symptoms, defined as a score of ≥4 on a 0-10 scale for at least one MENQOL item during eligibility screening.
Willing to adhere to all study-related procedures, including randomization to one of the two possible arms: acupuncture and WLC

Exclusion

Had been pregnant or lactating within 3 months prior to enrollment
History of hysterectomy or bilateral oophorectomy
Ongoing or planned radiation or surgery within 4 months from randomization
Use of acupuncture for menses recovery within 3 months of enrollment
Had been or will be receiving ovarian suppression medicine, such as leuprolide (Lupron) and goserelin (Zoladex), or hormonal contraception drugs within 3 months of enrollment or during the study period

What this trial measures

  • Enrollment rate1 year

    This is the proportion of patients who enroll in the study among those who are eligible and offered participation. Reason for not participating will be documented (e.g. time/commitment, not wanting to be randomized, does not want the study intervention).

  • Acupuncture treatment adherence rate.up to 16 weeks

    adherence rate is the proportion of patients randomized to the Acupuncture arm who are treatment adherent, defined as completing 10 or more of the 12 acupuncture sessions.