Lipid Infusions to Optimize Nutrition Trial for Bronchopulmonary Dysplasia

This study is looking at two different types of lipid (fat) infusions, called SOLE (soybean oil-based lipid emulsion) and MOLE (mixed oil lipid emulsion), to see which one is better for very premature babies. The goal is to find out if one of these infusions can help prevent bronchopulmonary dysplasia (BPD), a lung condition, and improve their overall health and development. Researchers will compare how well babies survive without BPD, their fatty acid levels, and signs of stress in their bodies. They will also look at how these infusions affect other health problems, long-term health, growth, and brain development at two years of age. You might be able to join if your baby was born very prematurely (under 28 weeks gestational age or weighing 1000g or less) and is between 12 hours and 28 weeks old. The study is currently unclear on its recruitment status.

Study design
This is an interventional study comparing two different lipid emulsions, SOLE and MOLE, in premature infants. It plans to enroll 230 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will assess participants for survival free of BPD at 36 weeks post menstrual age, and neurodevelopment at two years of age.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06915441

Lipid Infusions to Optimize Nutrition Trial

Recruiting
PHASE2Ages 12–28Interventional
The University of Texas Health Science Center, Houston
~230 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:SOLEMOLE

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants free of BPD (infants breathing in room air)
Measured over 36 weeks post menstrual age (PMA)
Bronchopulmonary Dysplasia
Neurodevelopmental Impairment
1 sites across 1 states
Texas1
  • Lindsay Holzapfel, MD, MS · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

inborn \<28 weeks gestational age (GA) or ≤1000g birth weight (BW)
survives until 12 hours after birth.

Exclusion

Infants who are unable to be enrolled by 96 hours postnatal age
Major anomaly
Overt non-bacterial infection
Infants likely to expire soon defined as limiting or withdrawal of intensive care recommended or requested by the parents.
  • Number of participants free of BPD (infants breathing in room air)36 weeks post menstrual age (PMA)