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Digital Interventions for Long-Term Memory in Aging

This study is exploring whether playing certain tablet games can help improve long-term memory and cognitive control in older adults, especially those with Mild Cognitive Impairment (MCI). Researchers will compare two different digital games: "Long Term Memory (LTM)", which involves navigating virtual neighborhoods, and "Worder", a word puzzle game similar to Boggle. You may be eligible if you are between 60 and 85 years old, have at least 12 years of education, and are fluent in English. The study aims to see if these games can improve your recognition and cued recall memory, with measurements taken before, right after training, and six months later. The current status of this study is unclear.

Study design
This is a randomized controlled trial with 150 participants. Participants will be randomly assigned to play one of two memory-based games.
What's involved
You will complete initial cognitive assessments and surveys (up to 120 minutes), then train with an assigned game for 45 minutes several days a week for up to 8 weeks (totaling 1000 minutes). All activities are completed remotely using a provided iPad.
Compensation
Not stated in the trial record.
Follow-up
Your memory will be tested six months after completing the training.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06916221

BID LTM Digital Intervention in Aging

Recruiting
NAAges 60–85InterventionalTreatment
University of California, San Francisco
~150 participants
Updated 2026-04-02 on ClinicalTrials.gov
What's tested:Long Term MemoryWorder

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MDT change in recognition memory
Measured over baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests
+1 more outcome measured

Conditions

Long-Term Memory
Inhibitory Control
Mild Cognitive Impairment

Explore related trials

Cognitive AgingMild cognitive disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Peter E Wais, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Melissa Arioli, AB
[email protected]
(415) 502-7321
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Minimum of 12 years of education
English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
Normal or corrected-to-normal vision
Normal or corrected-to-normal hearing
Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).

Exclusion

Under the age of 60
Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of \>4
Visually or hearing impaired without correction to normal
Regularly (one or more times per week) practicing an instrument within the last year
10 years or more of formal musical instrument training

What this trial measures

  • MDT change in recognition memorybaseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests

    Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures

  • TOUR change in cued recall memorybaseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests

    Psychometric test for proportion of details correctly recalled from recent autobiographical memory