This study is looking for adults aged 18 and older with knee osteoarthritis (OA) pain. The goal is to see how well subcutaneous (under the skin) injections of pentosan polysulfate sodium (PPS) work to reduce pain and improve function compared to a placebo (an inactive substance). You would be eligible if you have a clinical and X-ray diagnosis of knee OA. The main way we'll measure success is by tracking changes in your knee pain using a daily pain score over 112 days. Approximately 466 people will participate in this study. The current recruitment status is unclear.

Study design

This is a randomized, double-blind, placebo-controlled study, meaning participants are randomly assigned to receive either the study drug or placebo, and neither you nor your doctor will know which you are receiving. Approximately 466 participants will be enrolled.

What's involved

You would receive subcutaneous injections twice weekly for 6 weeks. The total study duration for each participant is up to 64 weeks, including a 7-week screening period and a 52-week follow-up period with visits every 4-6 weeks.

Compensation

Not stated in the trial record.

Follow-up

After the 6-week treatment period, participants will be followed for 52 weeks, with visits or contacts every 4-6 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.