Back to search results

Study of NiagenĀ®+ and NAD+ Injections for Healthy Aging

This study is looking at how well different forms of vitamin B3, called NiagenĀ® (nicotinamide riboside) and NAD+ (nicotinamide adenine dinucleotide), are tolerated when given as injections. Researchers want to see if these injections cause discomfort. You might be able to join if you are between 40 and 65 years old, in good general health, and live near the study site. The study aims to understand how people feel after receiving these injections, specifically looking at pain and discomfort right after the shot. The current recruitment status is unclear, but 70 people are planned to enroll.

Study design
This interventional study plans to enroll 70 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed for pain and discomfort at 1 minute after the injection is complete.

AI-generated from the public study record. Only the study team can confirm whether you're eligible ā€” confirm details with them before making decisions.

NCT06919328

Absorption and Tolerability of Injectable Administration of NiagenĀ®+, as Compared to NAD+

Recruiting
NAAges 40ā€“65Interventional
Nutraceuticals Research Institute
~70 participants
Updated 2025-04-09 on ClinicalTrials.gov
What's tested:NiagenĀ®NAD+Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
McGill Pain Questionnaire
Measured over 1 minute after injection is complete
+1 more outcome measured

Conditions

Healthy Aging

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Alabama1

Who to contact

JESSIE HAWKINS, PhD
[email protected]
2562039010
Email the study team

Opens a ready-to-send draft in your own email app ā€” review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation ā€” and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min Ā· HIPAA-protected Ā· delete anytime
Eligibility criteria

Inclusion

Provision of signed and dated informed consent form
Stated willingness and demonstrated ability to comply with all study procedures, as well as availability for the duration of the study
Lives within 100 miles of the NRI study site
Any gender, aged 40-65, inclusive
Good general health as evidenced by medical history
BMI 25-34.9 kg/m2
Sedentary behavior (defined as \<20 minutes per day or 100 minutes per week of moderate to vigorous exercise)
Demonstrated fatigue (Fatigue Assessment Scale) defined as a below-average score
For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional month after the end of the study
Agreement to adhere to Lifestyle Considerations throughout study duration

Exclusion

Current diagnosis of any seizure disorder, diabetes or insulin resistance, any kidney or liver disorder, heart disease, anemia, cancer, or Parkinson's disease
ANY chronic illness (pre-disease state acceptable)
Out of range phosphate levels at baseline
BMI less than 25 or greater than or equal to 35
Pregnancy, trying to conceive, or breastfeeding
Known allergic reactions to any components of the intervention or related compounds, including any form of B3
Positive COVID-19 test within 30 days of the study period
Recent dramatic weight changes (10% change in body weight in the last 6 months)
Existing usage of a NAD+ or NAD precursor supplement in any form (oral, nasal, patch, or injection/IV administration), including a B-complex supplement, within 60 days of the study, not including multivitamins.
Introducing a new medication, supplement, investigational drug, or other intervention (including lifestyle changes) within 60 days of the start of the study.

What this trial measures

  • McGill Pain Questionnaire1 minute after injection is complete

    The MPQ contains 78 pain related terms to identify the quantity and type of pain experienced. This multi-dimensional tool has three components; sensory, cognitive, emotional. Higher scores indicate higher levels of pain.

  • Subjective Discomfort1 minute after injection is complete

    Subjective discomfort is measured using open-ended questions to qualitatively assess participant comfort during injection.