This study is looking at two different antibiotic treatments to prevent infections after emergency trauma surgery. You might receive a single dose of ertapenem, or a combination of cefazolin and metronidazole. The study wants to see which treatment is better at preventing organ space surgical site infections (OS-SSI), which are infections deep inside the body after surgery. We are looking for adults aged 18 and older who need trauma surgery within 90 minutes of arriving at the hospital. We cannot include you if you are allergic to certain antibiotics, are pregnant or breastfeeding, or are a prisoner. The study will measure how many people get an OS-SSI within 30 days after their surgery. This study is currently recruiting about 300 participants.

Study design

This is an interventional study comparing two different antibiotic treatments. About 300 participants are expected to join.

What's involved

Participants will receive a single dose of antibiotics in the operating room. If you receive cefazolin, it may be re-dosed during surgery.

Compensation

Not stated in the trial record.

Follow-up

The study will track whether you develop an infection for 30 days after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.