POCUS-Guided Diuresis for Decompensated Heart Failure
This study is looking for people aged 18 or older who have acute decompensated heart failure (ADHF), meaning their heart failure symptoms have worsened and they need hospital care. The study aims to see if using point-of-care ultrasound (POCUS) to guide diuretic (water pill) treatment can help reduce how often people with ADHF are readmitted to the hospital within 30 days, and also lower the risk of acute kidney injury. You would either receive standard intravenous furosemide (a diuretic) with POCUS imaging for research only, or your treatment would be guided by POCUS measurements of your fluid status. To join, you must be planned for IV diuretics and have a specific abnormal POCUS measurement of your neck vein. The study plans to enroll 588 participants.
- Study design
- This is an interventional study comparing two approaches to diuretic management, with a planned enrollment of 588 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your readmission rate will be measured from hospital discharge until 30 days post-discharge. Acute kidney injury will be tracked from baseline to hospital discharge and up to 30 days post-discharge (if readmitted).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
POCUS-Guided Diuresis for Decompensated Heart Failure
At a glance
Conditions
NCT06921603
Where you'd take part
This study runs at 5 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
UPMC East
Pittsburgh, Pennsylvaniastudy coordinator listed
Not yet recruiting
UPMC Mercy
Pittsburgh, Pennsylvaniastudy coordinator listed
Not yet recruiting
UPMC Presbyterian
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
UPMC Shadyside
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- John J Pacella, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh Medical Center (UPMC)
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- 30-Day Readmission Rate in Acute Decompensated Heart Failure (ADHF) PatientsFrom date of hospital discharge until date of first readmission for heart failure or 30 days post-discharge, whichever comes first.
The percentage of participants readmitted to the hospital within 30 days of discharge for heart failure-related issues. The outcome compares the readmission rates between the POCUS-assessed diuretic management group and the standard care group.
- Incidence of Acute Kidney Injury (AKI)From baseline to hospital discharge and up to 30 days post-discharge (if readmitted).
The percentage of participants who develop acute kidney injury (AKI) during hospitalization or within 30 days post-discharge (if readmitted). Definition: AKI will be defined using the Acute Kidney Injury Network (AKIN) criteria: * Increase in serum creatinine by ≥0.3 mg/dL within 48 hours OR * Increase in serum creatinine by ≥50% from baseline OR * Reduced urine output (\<0.5 mL/kg/hr for ≥6 hours). Outcome Type: Binary (Yes/No)