Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia

This study is looking at whether using lung ultrasound (LUS) can help doctors decide if children with suspected pneumonia need antibiotics. Pneumonia in children can be hard to diagnose, and doctors sometimes prescribe antibiotics when they aren't needed. This study will compare using lung ultrasound to the usual way doctors diagnose pneumonia (physical exam, and sometimes X-rays or blood tests). Researchers want to see if lung ultrasound can reduce how often antibiotics are used. You might be able to join if you are a child between 3 and 10 years old, are generally healthy, and come to the emergency room with signs of a lung infection like a cough or fast breathing. The main goal is to see how many participants use antibiotics within 7 days.

Study design
This is a randomized study involving about 659 participants. You would be randomly assigned to either receive a lung ultrasound or standard care.
What's involved
If you are in the lung ultrasound group, you will have a lung ultrasound right after a clinical assessment. All participants will have routine evaluations, and doctors will decide on treatments like blood tests or antibiotics.
Compensation
Not stated in the trial record.
Follow-up
The study measures antibiotic use at 7 days after joining.

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NCT06921993

Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia

Recruiting
NAAges 3–10InterventionalDiagnostic
Meyer Children's Hospital IRCCS
~659 participants
Updated 2026-04-03 on ClinicalTrials.gov
What's tested:LUNG ULTRASOUND

At a glance

Recruiting sites
7 of 18 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants with antibiotic use
Measured over 7 days
Pneumonia Childhood
Pneumonia
Lung Ultrasound
Antibiotic Stewardship
18 sites across 6 states
Italy13
California1
Connecticut1
New York1
Wisconsin1
Israel1
  • Niccolò Parri, MD · STUDY_DIRECTOR · Meyer Children's Hospital IRCCS, Florence, Italy

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Eligibility criteria

Inclusion

Well-appearing, clinically stable patients aged 3 to 10 years, presenting to the pediatric ED with suspected pneumonia based on a combination of signs and symptoms suggestive of lower respiratory tract infection (LRTI), including:

Exclusion

Neonates and children up to 3 years of age, and children older than 10 years
Children aged 3 to 10 years with any of the following factors:
  • Percentage of participants with antibiotic use7 days

    A chart review and follow up phone call made at 1 week (range 5-7 days) to assess whether or not the subject was started on antibiotics during the index ED visit or at a later healthcare visit. The primary objective of this study is to determine if it is possible for LUS to reduce antibiotic prescription when evaluating patients with possible pneumonia. Specifically, an overall reduction of antibiotic when LUS is used as adjunct tool in the