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Hand Perfusion and Pulse Oximetry Performance Study

This observational study is looking at how well pulse oximeters (devices that measure oxygen in your blood through your finger) work compared to actual blood samples. Researchers will compare oxygen levels measured by pulse oximeters to oxygen levels from arterial blood gas samples (SaO2) taken at the same time. You would breathe different oxygen levels, and your hand's blood flow would be changed using adenosine (to increase blood flow) or norepinephrine (to decrease blood flow). This study is for healthy adults aged 18 to 65, with an equal number of men and women. The study aims to see if the pulse oximeter readings match the blood sample readings.

Study design
This is an observational study planning to enroll 20 healthy adult participants. It is not specified if it is randomized or blinded.
What's involved
You would be fitted with a mouthpiece or facemask to breathe different oxygen mixtures. Blood samples would be drawn at 30 minutes, 90 minutes, and 3 hours.
Compensation
Not stated in the trial record.
Follow-up
Oxygen saturation measurements will be taken at 30 minutes, 90 minutes, and 3 hours.

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NCT06925646

Hand Perfusion and Pulse Oximetry Performance

Not Yet Recruiting
Not specifiedAges 18–65Observational
Mayo Clinic
~20 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:Finger hyperperfusion via adenosineFinger hypoperfusion via by norepinephrineBaseline hypoxic test

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Arterial oxygen saturation measured via arterial blood gas sample (Sa02)
Measured over 30 minutes, 90 minutes, 3 hours
+1 more outcome measured

Conditions

Oxygen Saturation

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Michael Joyner, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Nancy Meyer
[email protected]
5072550913
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Eligibility criteria

Inclusion

Healthy adult men and women of all races and ethnic backgrounds recruited from faculty and staff of the Mayo Medical Center and from Rochester, MN and surrounding communities.
Equal number of male and female participants to address potential sex differences in physiology.
We will intentionally recruit subjects with dark skin because of the issues surrounding accuracy of pulse oximetry and skin tone.
Non-smokers
BMIs between 18-30 kg·m-2.
Female subjects will be non-pregnant.
Free of cardiopulmonary diseases or other conditions and/or taking medications that might affect pulse oximeter-based estimates of arterial saturation.
At least 8 of the subjects will have Fitzpatrick Skin Type of IV to VI.

What this trial measures

  • Arterial oxygen saturation measured via arterial blood gas sample (Sa02)30 minutes, 90 minutes, 3 hours

    Arterial oxygen saturation will be obtained via a blood sample at the end of each stage of the breath down protocols and is reported as a percentage.

  • Arterial oxygen saturation measured via pulse oximeters (Sp02)30 minutes, 90 minutes, 3 hours

    Arterial oxygen saturation will be obtained via pulse oximeter reading at the end of each stage of the breath down protocols and is reported as a percentage.