Orticumab for Inflammation in Coronary Arteries After Heart Attack

This study is testing a drug called orticumab to see if it can reduce inflammation in the coronary arteries (the blood vessels that supply the heart) in people who have had a heart attack. Participants will receive either orticumab or a placebo (an inactive substance) for 24 weeks. Researchers will compare how much the inflammation changes in the three main coronary arteries between the orticumab and placebo groups after 24 weeks. To join, you must be over 18 years old and have had a type-1 heart attack more than 180 days ago. The study aims to enroll 240 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 240 participants. It compares orticumab to a placebo, meaning some participants will receive the active drug and others will receive an inactive substance.
What's involved
You will need to attend planned study visits, provide complete medical history, and discuss any changes to your non-study treatments with the study doctor. Treatment will last for 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 24 weeks, indicating follow-up for at least this duration after starting treatment.

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NCT06927739

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

Recruiting
PHASE2Ages 18+InterventionalTreatment
Abcentra
~240 participants
Updated 2026-01-27 on ClinicalTrials.gov
What's tested:OrticumabPlacebo

At a glance

Recruiting sites
39 of 41 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent change from baseline of the mean Fat Attenuation Index (FAI) score for the 3 coronary arteries (RCA, LAD and LCX) for orticumab compared to placebo at 24 weeks
Measured over 24 weeks
Acute Coronary Syndromes
Coronary Arterial Disease (CAD)
Inflammation
Heart Disease
Myocardial Infarct
Atherosclerotic Coronary Vascular Disease
41 sites across 34 states
Central Hungary3
Lombardy3
California2
Madrid2
Stockholm County2
Florida1
Indiana1
Kentucky1

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  • Percent change from baseline of the mean Fat Attenuation Index (FAI) score for the 3 coronary arteries (RCA, LAD and LCX) for orticumab compared to placebo at 24 weeks24 weeks

    Analysis of the mean FAI score around the coronary arteries will be performed from baseline and 6-month Coronary Computed Tomography Angiography (CCTA) procedures. FAI-score is a standardized measurement of coronary inflammation for each coronary artery (adjusted for age, sex as well as technical, biological, and anatomical characteristics) to allow individualized interpretation of the degree of coronary inflammation. FAI-Score is given at a scale of 0-100 with arbitrary unit. A higher FAI-score indicates an increase coronary inflammation.