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Improving Family Communication for Hereditary Cancer Genetic Testing

This study is testing different web-based tools to help families communicate about their risk for hereditary cancer (cancers that run in families). Between 5% and 10% of all cancers are hereditary. Once a genetic change linked to cancer is found in one family member, other biological relatives can get tested to understand their own risk. This study uses a Communication Intervention (relative invitation tool), Health Promotion and Education (access to the VGN), and Informational Intervention (Genetic Testing Family Letter) to see if these tools encourage more relatives to get tested. We are looking for 625 participants, including adults aged 18 or older who have a confirmed hereditary cancer genetic change and have been seen at the University of Michigan Cancer Genetics Clinic, as well as their biological relatives. The study will measure how many family members use the invitation tool and how many invited relatives engage with genetic testing within 6 months.

Study design
This is an interventional study with an enrollment goal of 625 participants. It is not specified if participants are randomly assigned to different groups.
What's involved
Participants will engage with various web-based tools and may complete surveys. The study timeline for measuring primary outcomes is up to 6 months.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes are measured up to 6 months after the intervention.

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NCT06927947

Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes

Recruiting
NAAges 18+InterventionalPrevention
University of Michigan Rogel Cancer Center
~625 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:Communication InterventionHealth Promotion and EducationInformational InterventionSurvey Administration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of probands that utilize the invitation tool
Measured over Up to 6 Months
+1 more outcome measured

Conditions

Hereditary Malignant Neoplasm
Hereditary Neoplastic Syndrome

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Hereditary Neoplastic SyndromePHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS V PROTEIN

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Elena M Stoffel · PRINCIPAL_INVESTIGATOR · University of Michigan Rogel Cancer Center

Who to contact

MiGHT HelpLine
[email protected]
(734) 764-4044
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Eligibility criteria

Inclusion

PROBANDS: Clinically confirmed autosomal dominant pathogenic germline variant (PGV) associated with a hereditary cancer syndrome
PROBANDS: Previous evaluation by the University of Michigan (U-M) Cancer Genetics Clinic
PROBANDS: ≥ 18 years old
PROBANDS: Able to speak and read English
PROBANDS: Access to the internet
RELATIVES: Biological relative of proband
RELATIVES: ≥ 18 years old
RELATIVES: Able to speak and read English
RELATIVES: Access to the internet
RELATIVES: Have not completed germline genetic testing, per self-report at baseline

Exclusion

RELATIVES: Prior clinical germline genetic testing for cancer or already have an upcoming appointment scheduled with a genetics provider, per self-report at baseline

What this trial measures

  • Percentage of probands that utilize the invitation toolUp to 6 Months

    Will be defined as inviting at least 1 eligible at-risk relative. Will be assessed using descriptive statistics. Will be tabulated and summarized. Continuous variables will be summarized by mean, median, and standard deviation; histograms and boxplots will be used to further assess distributional characteristics of these variables. Categorical variables will be tabulated with frequencies and percentages. Will be estimated and presented along with a 95% confidence interval.

  • Percentage of invited relatives that engageUp to 6 Months

    Will be defined as enrolling in the study and accessing the informational content (letter and/or virtual genetics navigator) at least 1 time. Will be assessed using descriptive statistics. Will be tabulated and summarized. Continuous variables will be summarized by mean, median, and standard deviation; histograms and boxplots will be used to further assess distributional characteristics of these variables. Categorical variables will be tabulated with frequencies and percentages. Will be estimated and presented along with a 95% confidence interval.