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Improving the Taste of Pediatric Medicines

This study aims to make liquid medicines taste better for children and others who can't swallow pills. Many medicines have a bad taste, which can make it hard for patients to take them. Researchers are looking for flavor additives that can block bitter tastes in active pharmaceutical ingredients (the substances in medicines that make them work). You can join if you are a healthy adult between 18 and 60 years old. You will taste different liquid or gel samples containing these ingredients and rate their flavor intensity. The study will measure how well these flavor additives work to improve taste, with results collected over a period of about 2 months to 3 years.

Study design
This interventional study plans to enroll 100 healthy adults. It is not specified if it is randomized, blinded, or its phase.
What's involved
You will attend repeated visits to Monell for sensory testing. You will need to avoid eating or drinking for at least 1 hour before sessions and remain on site for one hour after tasting samples.
Compensation
Not stated in the trial record.
Follow-up
Your flavor intensity ratings will be measured through study completion, which could be between about 2 months and 3 years, depending on how many samples you evaluate.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06929455

Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines

Recruiting
NAAges 18–60InterventionalBasic science
Monell Chemical Senses Center
~100 participants
Updated 2025-04-16 on ClinicalTrials.gov
What's tested:Flavor additives

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ratings of flavor intensity
Measured over Through study completion, between about 2 months and 3 years, depending on the number of API-flavor combinations individual participants choose to evaluate

Conditions

Healthy Adults

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Paul M Wise, Ph.D. · PRINCIPAL_INVESTIGATOR · Monell Chemical Senses Center

Who to contact

Paul M Wise, Ph.D.
[email protected]
267-519-4799
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Between the ages of 18 and 60;
Generally healthy by self-report;
All races/ethnicities, both men and women;
Able to provide informed consent;
Able to attend repeated visits to Monell for sensory testing;
Willing to follow instructions (e.g., refrain from eating or drinking for at least 1 hour before sessions, willing to remain on site for one hour after tasting an API that the participant has never tasted before). -

Exclusion

Under 18 or over 60;
Pregnant, nursing, or plans to become pregnant;
Unable to provide consent (including limited ability to understand written and spoken English);
Tobacco, vape, marijuana, or tetrahydrocannabinol cartridge users. We will accept people who have used tobacco or marijuana products on occasion, but not regular users;
Known drug or food allergies of any kind;
Diabetes or other metabolic disorder;
Liver issues of any kind, including viral hepatitis;
Kidney issues of any kind;
Other chronic illness, including cardiovascular, neurological, immune disorders, or any other serious acute or chronic condition
Dentures or other major dental implants;
Condition affecting the oral cavity, including dry mouth, burning mouth syndrome, active sores or blisters, geographic tongue, or other disorders
Current infection or cold, flu, or infection with SARS-CoV-2 within the last four weeks;
Unable to taste or smell
Daily use, or use within the last four weeks, of either prescription or over-the-counter medications (except for birth control)
History of tuberculosis (including latent tuberculosis), positive skin or other tuberculosis test at any time in the past, birth in or residence in a country with high tuberculosis rates, known contact with someone who is tuberculosis positive
HIV infection

What this trial measures

  • Ratings of flavor intensityThrough study completion, between about 2 months and 3 years, depending on the number of API-flavor combinations individual participants choose to evaluate

    Ratings of oral sensation (e.g., bitterness, sourness, astringency, etc.) made using the general Labeled Magnitude Scale. Values range from 0 (no sensation) to 100 (strongest imaginable sensation)