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MitoQ and Ischemic Conditioning for Stroke Survivors

This study is looking at ways to improve blood vessel health in people who have had a stroke. Researchers are testing two different approaches: Ischemic Conditioning, which involves briefly inflating a cuff on your thigh, and MitoQ, an over-the-counter antioxidant supplement. They want to see if either of these can improve how well your blood vessels work. You might be able to join if you are 18-85 years old, had a stroke at least six months ago with some weakness on one side of your body, can give informed consent, and speak English. The study aims to measure changes in how your blood vessels expand (Flow-Mediated Dilation and Microvascular Vasodilation) five hours after the intervention. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is an interventional study with 30 planned participants. The phase of the study is not specified.
What's involved
Participants will receive either Ischemic Conditioning (five cycles of cuff inflation and release for 45 minutes) or a single oral dose of 80mg of MitoQ or a placebo pill. Blood vessel function will be measured five hours after the intervention.
Compensation
Not stated in the trial record.
Follow-up
Blood vessel function will be measured five hours after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06930638

MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

Recruiting
PHASE2Ages 18–85Interventional
Medical College of Wisconsin
~30 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:Ischemic ConditioningAntioxidant Supplement

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Brachial Artery Flow-Mediated Dilation
Measured over Change from BL to Post Intervention (5 hours)
+1 more outcome measured

Conditions

Stroke

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Stroke

NCT06930638

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical College of Wisconsin

    Milwaukee, Wisconsinstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Matthew Durand, PhD · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

Who to contact

Jennifer Nguyen
[email protected]
414-955-5713
Email the study team

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Eligibility criteria

Inclusion

18 - 85 years of age
Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
Able to give informed consent and follow 2-step command.
English Speaking

Exclusion

Unable to stand from chair without physical assistance from another person (able to use assistive device).
History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
History of head trauma or concussion within the past 6 months
Comorbid neurological disorder
Peripheral vascular disease
Myocardial infarction or arrhythmia in the previous year
Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
Pregnant or breastfeeding.
Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator

What this trial measures

  • Brachial Artery Flow-Mediated DilationChange from BL to Post Intervention (5 hours)

    We will measure brachial artery vascular health in the non-paretic arm. Baseline brachial artery diameter and blood flow velocity through the artery will be measured before and after a pneumatic forearm cuff is inflated to 225 mmHg for five minutes.

  • Microvascular VasodilationChange from BL to Post Intervention (5 hours)

    Laser Doppler Flowmetry (LDF) with Dermal Microdialysis (DM) will measure blood flow flux during microinfusions of study drugs (limited to an area on the skin approximately the size of a nickel) to examine endothelial dependent vasodilation (Acetylcholine, ACh) and nitric-oxide mediated vasodilation (ACH +/- LNAME, and endothelial nitric oxide synthase inhibitor).