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Occupational Cancer Screening in Firefighters Study

This study is looking at different ways to screen firefighters for cancer. Firefighters have a higher risk of cancer due to their job. Researchers want to see how well whole-body MRI (Magnetic Resonance Imaging), whole-body ultrasound, and a special blood test called MCD Assay work to find early signs of cancer. The MCD Assay is an investigational test, meaning it's not yet approved by the FDA. Whole-body MRI and ultrasound are FDA-approved for diagnosing some cancers when other signs of disease are present. This study aims to enroll 800 firefighters, aged 35 to 85, who have worked as a firefighter for at least 10 years and are currently active. The main goal is to see how many pre-cancers and cancers each screening method finds within about a year.

Study design
This interventional study plans to enroll 800 participants. Participants will be randomly assigned to one of two whole-body imaging screening groups.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 1 year (plus or minus 2 months) to see how many pre-cancers and cancers are detected.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06931561

Occupational Cancer Screening in Firefighters: A Pilot Study Within the Inova Health System

Recruiting
NAAges 35–85InterventionalScreening
Inova Health Care Services
~800 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Whole Body MRIWhole Body UltrasoundMCD AssayOccupational Exposure Questionnaire

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of confirmed pre-malignancies detected with each investigational screening tool
Measured over up to 1 year (± 2 months)
+1 more outcome measured

Conditions

Cancer

Explore related trials

Malignant Neoplasm

Where it's being run

1 sites across 1 states
Virginia1

Study leadership

  • Stephanie Van Bebber · STUDY_DIRECTOR · Inova Health System - Inova Schar Cancer
  • Rebecca Kaltman, MD · PRINCIPAL_INVESTIGATOR · Inova Health System - Saville Cancer Screening and Prevention Center

Who to contact

Salman Baig
[email protected]
(571) 472-3500
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥ 35 years old
at least 10 cumulative years working as a firefighter
Actively serving as a firefighter (active or volunteer) with completion of NFPA physical examination within the past 6 months
Ability to understand and willing to sign informed consent
Ability to understand and willing to sign the Health Insurance Portability and Accountability Act (HIPAA) Authorization
Additional eligibility criteria in protocol

Exclusion

No prior history of any invasive cancer within the previous 5 years (non-melanoma skin cancer and in situ carcinoma would still be eligible) and no current diagnostic workup for suspicion of cancer
Received a whole-body MRI, whole-body ultrasound, or been tested with a MCD within the past 1-year
For women of childbearing potential, pregnancy and no plans for pregnancy for the duration of the study

What this trial measures

  • Number of confirmed pre-malignancies detected with each investigational screening toolup to 1 year (± 2 months)

    The number of confirmed pre-malignancies detected using whole-body Magnetic Resonance Imaging (MRI), whole-body ultrasound, or the Multi Cancer Detection (MCD) test

  • Number of confirmed malignancies detected with each investigational screening toolup to 1 year (± 2 months)

    The number of confirmed malignancies detected using whole-body Magnetic Resonance Imaging (MRI), whole-body ultrasound, or the Multi Cancer Detection (MCD) test