Adult Congenital Heart Disease and SGLT2 Inhibitors Registry

This international registry is looking at how a type of medication called SGLT2 inhibitors (sodium-glucose cotransporter 2 inhibitors) is currently being used in adults with congenital heart disease (heart problems present from birth). The study wants to understand how these drugs are prescribed, if they are safe and well-tolerated, and if they help with heart failure symptoms. You may be able to join if you are an adult (18 years or older) with a congenital heart defect and have already started taking an SGLT2 inhibitor. The main goal is to see how these medications are being prescribed at the beginning of the study.

Study design
This is an observational study, meaning researchers will collect information without giving you a specific treatment. It aims to include 400 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06932081

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

Recruiting
Not specifiedAges 18+Observational
Leiden University Medical Center
~400 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:SGLT2 inhibitors

At a glance

Recruiting sites
11 of 11 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prescription patterns
Measured over Baseline information.
Adult Congenital Heart Disease
Congenital Heart Disease
Systemic Right Ventricle
Transposition of the Great Arteries
Congenitally Corrected Transposition of the Great Arteries
Fontan
Single Ventricle
Tetralogy of Fallot (TOF)
11 sites across 8 states
United Kingdom3
Netherlands2
Maryland1
Michigan1
New York1
Germany1
South Holland1
North Macedonia1
  • Anastasia D. Egorova, MD PhD · PRINCIPAL_INVESTIGATOR · Leiden University Medical Center

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Eligibility criteria

Inclusion

Congenital heart defect.
Age ≥ 18 years.
Initiated on treatment with an SGLT2i.
  • Prescription patternsBaseline information.

    The primary outcome of this registry is an overview of the prescription patterns of SGLT2i in the ACHD population.