Observational Study of Brain Blood Flow in Subarachnoid Hemorrhage

This observational study aims to understand how blood flow to the brain changes in patients who have experienced a subarachnoid hemorrhage (SAH), which is bleeding on the surface of the brain. Researchers will use a non-invasive device called Near-Infrared Spectroscopy (NIRS) (HEM1 with Foresight Elite Sensor) to continuously monitor brain oxygen levels. The main goal is to see if the ideal blood pressure for the brain changes over time in SAH patients, and if problems with the brain's ability to regulate its own blood flow contribute to delayed brain injury. This study is for patients aged 18 to 89 who are admitted to the Neuro ICU for aneurysmal SAH between March 2025 and December 2026. The study will measure changes in the Lower Limit of Autoregulation (LLA) over 21 days.

Study design
This is an observational study involving 120 participants. It is not testing a new treatment but rather observing how the brain's blood flow regulation changes in patients with subarachnoid hemorrhage.
What's involved
You would have a non-invasive NIRS device connected, which automatically captures brain oxygen data and stores it. The study will measure changes over 21 days.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 21 days, indicating monitoring for at least that duration.

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NCT06932640

Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)

Not Yet Recruiting
Not specifiedAges 18–89Observational
University of Alabama at Birmingham
~120 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:- Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Lower Limit of Autoregulation (LLA)
Measured over 21 days
Subarachnoid Hemorrhage, Aneurysmal
1 sites across 1 states
Alabama1
  • Weifeng Song, M.D., Ph.D · PRINCIPAL_INVESTIGATOR · The University of Alabama at Birmingham

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Eligibility criteria

Inclusion

Patients aged 18 to 89 years who are admitted to the Neurological Intensive Care Unit (Neuro ICU) between March 2025 and December 2026 for aneurysmal subarachnoid hemorrhage (SAH).

Exclusion

Patients under 18 years old
Prisoners
Pregnant women
Patients enrolled in concurrent ongoing interventional trial
Students of UAB
Employees of UAB
Patients who undergoes frontal decompression surgery resulting bone flap deficit where NIRS monitoring pads could not be applied.
  • Change in Lower Limit of Autoregulation (LLA)21 days

    Successful calculations of moving Lower Limit of Autoregulation (LLA) for all three algorithms