Optimizing DHA Delivery for Cognitive Decline in Older Adults

This study is looking for adults aged 55 to 82 who are experiencing early signs of memory or cognitive (thinking) decline. The purpose is to see if a special form of omega-3 fatty acids, called LPC-EPA+DHA (Lysoveta), can better deliver DHA to the brain compared to another form, TAG-DHA. Researchers will measure DHA levels in your cerebrospinal fluid (the fluid around your brain and spinal cord) and blood after 24 weeks of taking capsules. They also hope to see improvements in markers related to brain health. This is a placebo-controlled study, meaning some participants will receive an inactive substance, to help understand the true effects of the intervention. The study is currently unclear about its recruitment status and aims to enroll 153 participants.

Study design
This is an interventional, placebo-controlled study comparing LPC-EPA+DHA and TAG-DHA in 153 elderly adults.
What's involved
Participants will take capsules for 24 weeks. A lumbar puncture (spinal tap) to collect cerebrospinal fluid may be required, unless there's a medical reason not to have one.
Compensation
Not stated in the trial record.
Follow-up
DHA levels will be measured from baseline through week 24.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06933095

Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia

Recruiting
NAAges 55–82InterventionalBasic science
University of Cincinnati
~153 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
CSF Docosahexaenoic acid (DHA) levels
Measured over From baseline through week 24
Eldery People
Cognitive Decline
Memory Decline
DHA CNS Delivery

NCT06933095

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Cincinnati, Department of Psychiatry and Behavioral Neuroscience

    Cincinnati, Ohiostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Robert McNamara, PhD · PRINCIPAL_INVESTIGATOR · University of Cincinnati

Opens a ready-to-send draft in your own email app — review before sending.

  • CSF Docosahexaenoic acid (DHA) levelsFrom baseline through week 24

    Baseline-Endpoint change in CSF docosahexaenoic acid (DHA) composition (g/100 g).