Subcortical Arousal in Perceptual Awareness Study

This study is looking into how certain brain areas, called subcortical arousal systems, help us perceive things like sights, sounds, and touch. Researchers will use different tools to understand this, including EEG (a test that measures brain waves from your scalp), eye tracking (to watch your eye movements and pupil changes), and fMRI (a type of MRI that looks at brain activity). You'll also complete behavioral tasks where you report what you see. The study includes healthy volunteers aged 13 and older, and patients with epilepsy. The main goals are to see how these subcortical signals change, how well people perceive things, and what brain activity changes occur immediately after these tests.

Study design
This interventional study plans to enroll 202 participants, including healthy individuals and patients with epilepsy. It will use fMRI, eye tracking, and behavioral tasks.
What's involved
You would undergo EEG, eye tracking, and fMRI scans. You would also complete behavioral tasks where you report on visual stimuli.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as subcortical signals and perceptual sensitivity, are measured immediately after the interventions.

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NCT06934356

Subcortical Arousal in Perceptual Awareness

Recruiting
NAAges 13+InterventionalTreatment
Yale University
~202 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:EEGEye TrackingBehavioral taskfMRI

At a glance

Recruiting sites
7 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Subcortical event-related signals
Measured over Immediately after the intervention
+3 more outcomes measured
Epilepsy
8 sites across 8 states
Connecticut1
Kansas1
Massachusetts1
Minnesota1
New Hampshire1
Pennsylvania1
Tennessee1
Texas1
  • Hal Blumenfeld, MD, Phd · PRINCIPAL_INVESTIGATOR · Yale University

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  • Subcortical event-related signalsImmediately after the intervention

    Subcortical event-related signals will be recorded by icEEG to assess electrical activity from the cerebral cortex using currently implanted electrodes during the behavioral task

  • Perceptual SensitivityImmediately after the intervention

    measured by the percentage of correctly perceived trials for each participant (Aim 3B)

  • Activity changesImmediately after the intervention

    Measured using functional magnetic resonance imaging (fMRI) during task onset and off-set to fixation and compare them to fMRI changes during conscious perception of a stimulus vs. not-reported stimuli (Aims 1 and 2)

  • Functional connectivityImmediately after the intervention

    Measured using fMRI to establish networks actively engaged during task vs. fixation and consciously-reported vs. not-reported stimuli (Aims 1 and 2).